Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2098215..2099046 Replicon chromosome
Accession NZ_CP019008
Organism Escherichia coli strain Ecol_AZ159

Toxin (Protein)


Gene name yeeV Uniprot ID A0A768PNB2
Locus tag BE939_RS11550 Protein ID WP_061157912.1
Coordinates 2098215..2098589 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A785EPM7
Locus tag BE939_RS11555 Protein ID WP_001535568.1
Coordinates 2098678..2099046 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE939_RS11515 2093611..2094777 + 1167 WP_061157914.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
BE939_RS11520 2094896..2095369 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
BE939_RS11525 2095567..2096625 + 1059 WP_001200890.1 FUSC family protein -
BE939_RS11530 2096797..2097126 + 330 WP_000450409.1 DUF496 family protein -
BE939_RS11535 2097227..2097409 - 183 WP_061157913.1 ethanolamine utilization protein -
BE939_RS11540 2097463..2097609 + 147 Protein_1928 transposase domain-containing protein -
BE939_RS26425 2097898..2098011 - 114 WP_001161660.1 DUF957 domain-containing protein -
BE939_RS11545 2098024..2098218 - 195 WP_000988601.1 hypothetical protein -
BE939_RS11550 2098215..2098589 - 375 WP_061157912.1 type IV toxin-antitoxin system toxin CbtA Toxin
BE939_RS11555 2098678..2099046 - 369 WP_001535568.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
BE939_RS11560 2099120..2099341 - 222 WP_061157911.1 DUF987 domain-containing protein -
BE939_RS11565 2099404..2099880 - 477 WP_001186786.1 RadC family protein -
BE939_RS11570 2099896..2100375 - 480 WP_061157910.1 antirestriction protein -
BE939_RS11575 2100638..2101459 - 822 WP_001234571.1 DUF945 domain-containing protein -
BE939_RS11585 2101680..2102090 - 411 WP_061157909.1 hypothetical protein -
BE939_RS11590 2102106..2102783 - 678 WP_001362823.1 hypothetical protein -
BE939_RS11595 2102919..2103989 - 1071 WP_061157908.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13871.91 Da        Isoelectric Point: 7.8522

>T71406 WP_061157912.1 NZ_CP019008:c2098589-2098215 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNSITLGKYPEAK

Download         Length: 375 bp

>T71406 NZ_CP019008:c2098589-2098215 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAGCATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13481.26 Da        Isoelectric Point: 5.0468

>AT71406 WP_001535568.1 NZ_CP019008:c2099046-2098678 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLSSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLACEADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT71406 NZ_CP019008:c2099046-2098678 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
CCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCAATCAGCATACCGTCACGCTGTATGCGAAGGGGCTGGCCTGTGAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A768PNB2

Antitoxin

Source ID Structure
AlphaFold DB A0A785EPM7

References