Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1017393..1018228 Replicon chromosome
Accession NZ_CP019008
Organism Escherichia coli strain Ecol_AZ159

Toxin (Protein)


Gene name yeeV Uniprot ID F4TIK8
Locus tag BE939_RS06340 Protein ID WP_000854694.1
Coordinates 1017393..1017770 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4TIK7
Locus tag BE939_RS06345 Protein ID WP_001285605.1
Coordinates 1017860..1018228 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE939_RS06315 1012521..1013669 - 1149 WP_000905922.1 capsule polysaccharide export inner-membrane protein KpsE -
BE939_RS06320 1013741..1014724 - 984 WP_061157979.1 KpsF/GutQ family sugar-phosphate isomerase -
BE939_RS06325 1015535..1015705 - 171 Protein_952 IS110 family transposase -
BE939_RS06330 1016047..1016889 - 843 WP_001290171.1 DUF4942 domain-containing protein -
BE939_RS26320 1016974..1017171 - 198 WP_086795284.1 DUF957 domain-containing protein -
BE939_RS26325 1017247..1017396 - 150 Protein_955 hypothetical protein -
BE939_RS06340 1017393..1017770 - 378 WP_000854694.1 TA system toxin CbtA family protein Toxin
BE939_RS06345 1017860..1018228 - 369 WP_001285605.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BE939_RS06350 1018308..1018529 - 222 Protein_958 DUF987 domain-containing protein -
BE939_RS06355 1018616..1019092 - 477 WP_001696592.1 RadC family protein -
BE939_RS06360 1019108..1019587 - 480 WP_001696591.1 antirestriction protein -
BE939_RS06365 1019853..1020671 - 819 WP_001175153.1 DUF945 domain-containing protein -
BE939_RS06370 1020761..1020994 - 234 WP_001278287.1 DUF905 family protein -
BE939_RS06375 1021000..1021677 - 678 WP_001097368.1 hypothetical protein -
BE939_RS06380 1021796..1022680 - 885 WP_000010392.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1015920..1076263 60343


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14008.02 Da        Isoelectric Point: 7.7293

>T71403 WP_000854694.1 NZ_CP019008:c1017770-1017393 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T71403 NZ_CP019008:c1017770-1017393 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.48 Da        Isoelectric Point: 6.0601

>AT71403 WP_001285605.1 NZ_CP019008:c1018228-1017860 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRACIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT71403 NZ_CP019008:c1018228-1017860 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCTGTATTAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M2F934

Antitoxin

Source ID Structure
AlphaFold DB A0A2U2V3N6

References