Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2999887..3000413 | Replicon | chromosome |
| Accession | NZ_CP019005 | ||
| Organism | Escherichia coli strain Ecol_AZ155 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | BE948_RS18000 | Protein ID | WP_000323025.1 |
| Coordinates | 2999887..3000174 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | BE948_RS18005 | Protein ID | WP_000534858.1 |
| Coordinates | 3000174..3000413 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BE948_RS17960 | 2994911..2995126 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| BE948_RS27945 | 2995346..2995516 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| BE948_RS17965 | 2995880..2996095 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| BE948_RS17970 | 2996396..2996608 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| BE948_RS27640 | 2996663..2996752 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| BE948_RS17975 | 2997030..2997782 | - | 753 | WP_001047135.1 | antitermination protein | - |
| BE948_RS17980 | 2997796..2998845 | - | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| BE948_RS17985 | 2998847..2999125 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| BE948_RS17990 | 2999192..2999443 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| BE948_RS17995 | 2999660..2999815 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| BE948_RS18000 | 2999887..3000174 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| BE948_RS18005 | 3000174..3000413 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| BE948_RS18010 | 3000438..3000743 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| BE948_RS18015 | 3000946..3001278 | + | 333 | WP_001301033.1 | protein FlxA | - |
| BE948_RS18020 | 3001715..3003028 | - | 1314 | WP_000589005.1 | ISNCY family transposase | - |
| BE948_RS27950 | 3003797..3004084 | - | 288 | Protein_2806 | hypothetical protein | - |
| BE948_RS18040 | 3004306..3004710 | + | 405 | WP_000839179.1 | IS66 family insertion sequence hypothetical protein | - |
| BE948_RS18045 | 3004707..3005054 | + | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2964845..3015993 | 51148 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T71378 WP_000323025.1 NZ_CP019005:c3000174-2999887 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T71378 NZ_CP019005:c3000174-2999887 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT71378 WP_000534858.1 NZ_CP019005:c3000413-3000174 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT71378 NZ_CP019005:c3000413-3000174 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|