Detailed information of TA system TA071354

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3943738..3944558
• Replicon: chromosome
• Accession: NZ_CP019000
• Organism: Escherichia coli strain Ecol_AZ153

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: BE940_RS22330
• Protein ID: WP_001054379.1
• Coordinates: 3944301..3944558 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: BE940_RS22325
• Protein ID: WP_000123957.1
• Coordinates: 3943738..3944289 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BE940_RS22295	3939432..3940745	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
BE940_RS22300	3940757..3941035	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
BE940_RS22305	3941032..3942153	-	1122	WP_000010833.1	M42 family metallopeptidase	-
BE940_RS28815	3942398..3942514	-	117	Protein_3754	VOC family protein	-
BE940_RS22315	3942552..3942812	-	261	WP_000077645.1	hypothetical protein	-
BE940_RS22320	3942940..3943686	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
BE940_RS22325	3943738..3944289	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
BE940_RS22330	3944301..3944558	-	258	WP_001054379.1	YjhX family toxin	Toxin
BE940_RS22335	3944935..3945099	-	165	Protein_3759	GNAT family N-acetyltransferase	-
BE940_RS22345	3946342..3947448	+	1107	Protein_3761	helicase YjhR	-
BE940_RS22355	3948031..3949011	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T71354 WP_001054379.1 NZ_CP019000:c3944558-3944301 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T71354 NZ_CP019000:c3944558-3944301 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT71354 WP_000123957.1 NZ_CP019000:c3944289-3943738 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT71354 NZ_CP019000:c3944289-3943738 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030