Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2365196..2366030 | Replicon | chromosome |
| Accession | NZ_CP019000 | ||
| Organism | Escherichia coli strain Ecol_AZ153 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | BE940_RS14290 | Protein ID | WP_078215041.1 |
| Coordinates | 2365653..2366030 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1P7N8 |
| Locus tag | BE940_RS14285 | Protein ID | WP_001305076.1 |
| Coordinates | 2365196..2365564 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BE940_RS14240 | 2360278..2361405 | + | 1128 | Protein_2291 | hypothetical protein | - |
| BE940_RS14245 | 2361481..2361936 | + | 456 | WP_000581502.1 | hypothetical protein | - |
| BE940_RS14250 | 2362015..2362248 | + | 234 | WP_000902034.1 | DUF905 family protein | - |
| BE940_RS14260 | 2362349..2363167 | + | 819 | WP_001234620.1 | DUF945 domain-containing protein | - |
| BE940_RS14265 | 2363222..2363707 | + | 486 | WP_000849565.1 | antirestriction protein | - |
| BE940_RS14270 | 2363723..2364199 | + | 477 | WP_001186726.1 | RadC family protein | - |
| BE940_RS14275 | 2364262..2364483 | + | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| BE940_RS14280 | 2364502..2365146 | + | 645 | WP_000094916.1 | hypothetical protein | - |
| BE940_RS14285 | 2365196..2365564 | + | 369 | WP_001305076.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| BE940_RS14290 | 2365653..2366030 | + | 378 | WP_078215041.1 | TA system toxin CbtA family protein | Toxin |
| BE940_RS14295 | 2366027..2366515 | + | 489 | WP_000761699.1 | hypothetical protein | - |
| BE940_RS14300 | 2366532..2366729 | + | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| BE940_RS14305 | 2366814..2367659 | + | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| BE940_RS14310 | 2367728..2368123 | + | 396 | WP_000208384.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| BE940_RS14315 | 2368116..2369049 | + | 934 | Protein_2305 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| BE940_RS28485 | 2369481..2369636 | + | 156 | WP_000729638.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / kpsM / kpsT | 2320918..2385895 | 64977 | |
| - | flank | IS/Tn | - | - | 2369481..2369636 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14003.99 Da Isoelectric Point: 8.2905
>T71347 WP_078215041.1 NZ_CP019000:2365653-2366030 [Escherichia coli]
MKTLPDTHVRAASCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T71347 NZ_CP019000:2365653-2366030 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13560.39 Da Isoelectric Point: 4.7830
>AT71347 WP_001305076.1 NZ_CP019000:2365196-2365564 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
Download Length: 369 bp
>AT71347 NZ_CP019000:2365196-2365564 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|