Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2220283..2220937 Replicon chromosome
Accession NZ_CP019000
Organism Escherichia coli strain Ecol_AZ153

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag BE940_RS13425 Protein ID WP_000244765.1
Coordinates 2220283..2220690 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag BE940_RS13430 Protein ID WP_000354050.1
Coordinates 2220671..2220937 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE940_RS13405 2216240..2217973 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
BE940_RS13410 2217979..2218689 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BE940_RS13415 2218714..2219610 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
BE940_RS13420 2219722..2220243 + 522 WP_001055874.1 flavodoxin FldB -
BE940_RS13425 2220283..2220690 - 408 WP_000244765.1 protein YgfX Toxin
BE940_RS13430 2220671..2220937 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
BE940_RS13435 2221180..2222160 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
BE940_RS13440 2222237..2222896 - 660 WP_000250275.1 hemolysin III family protein -
BE940_RS13445 2223060..2223371 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
BE940_RS13450 2223416..2224849 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T71346 WP_000244765.1 NZ_CP019000:c2220690-2220283 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T71346 NZ_CP019000:c2220690-2220283 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT71346 WP_000354050.1 NZ_CP019000:c2220937-2220671 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT71346 NZ_CP019000:c2220937-2220671 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References