Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1286915..1287746 Replicon chromosome
Accession NZ_CP019000
Organism Escherichia coli strain Ecol_AZ153

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag BE940_RS09050 Protein ID WP_000854815.1
Coordinates 1287372..1287746 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag BE940_RS09045 Protein ID WP_001280918.1
Coordinates 1286915..1287283 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE940_RS08995 1282004..1282750 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
BE940_RS09000 1282833..1283183 + 351 Protein_1323 hypothetical protein -
BE940_RS09005 1283199..1283609 + 411 WP_000846703.1 hypothetical protein -
BE940_RS09015 1283830..1284648 + 819 WP_001542275.1 DUF945 domain-containing protein -
BE940_RS09020 1284648..1284893 + 246 WP_001164966.1 hypothetical protein -
BE940_RS09025 1284987..1285460 + 474 WP_001542276.1 antirestriction protein -
BE940_RS09030 1285476..1285952 + 477 WP_001186200.1 RadC family protein -
BE940_RS09035 1286015..1286236 + 222 WP_000692345.1 DUF987 domain-containing protein -
BE940_RS09040 1286255..1286899 + 645 WP_000086752.1 hypothetical protein -
BE940_RS09045 1286915..1287283 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BE940_RS09050 1287372..1287746 + 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
BE940_RS09055 1287743..1287937 + 195 WP_000988600.1 hypothetical protein -
BE940_RS27915 1287950..1288063 + 114 WP_001161660.1 DUF957 domain-containing protein -
BE940_RS09060 1288352..1288498 - 147 Protein_1335 transposase domain-containing protein -
BE940_RS09065 1288552..1288734 + 183 WP_001296208.1 hypothetical protein -
BE940_RS09070 1288835..1289164 - 330 WP_000450409.1 DUF496 family protein -
BE940_RS09075 1289336..1290394 - 1059 WP_001200889.1 FUSC family protein -
BE940_RS09080 1290592..1291065 - 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
BE940_RS09085 1291184..1292350 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T71344 WP_000854815.1 NZ_CP019000:1287372-1287746 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T71344 NZ_CP019000:1287372-1287746 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT71344 WP_001280918.1 NZ_CP019000:1286915-1287283 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT71344 NZ_CP019000:1286915-1287283 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References