Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4269634..4270435 Replicon chromosome
Accession NZ_CP018991
Organism Escherichia coli strain Ecol_AZ146

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag BE932_RS24220 Protein ID WP_061091468.1
Coordinates 4270058..4270435 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag BE932_RS24215 Protein ID WP_032215284.1
Coordinates 4269634..4270011 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE932_RS24165 4265303..4265845 + 543 WP_033811096.1 hypothetical protein -
BE932_RS24170 4266206..4266688 + 483 WP_077777324.1 hypothetical protein -
BE932_RS24185 4267056..4267877 + 822 WP_061091467.1 DUF945 domain-containing protein -
BE932_RS24190 4267877..4268122 + 246 WP_000680586.1 hypothetical protein -
BE932_RS24195 4268216..4268689 + 474 WP_000855069.1 antirestriction protein -
BE932_RS24200 4268705..4269181 + 477 WP_001186774.1 RadC family protein -
BE932_RS24205 4269250..4269471 + 222 WP_000692307.1 DUF987 domain-containing protein -
BE932_RS24215 4269634..4270011 + 378 WP_032215284.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BE932_RS24220 4270058..4270435 + 378 WP_061091468.1 TA system toxin CbtA family protein Toxin
BE932_RS24225 4270432..4270860 + 429 Protein_4099 hypothetical protein -
BE932_RS24230 4270834..4271751 - 918 WP_000520337.1 IS5-like element ISEc35 family transposase -
BE932_RS24235 4272000..4272197 + 198 WP_061091469.1 DUF957 domain-containing protein -
BE932_RS24240 4272294..4272854 + 561 Protein_4102 DUF4942 domain-containing protein -
BE932_RS24245 4272926..4273930 + 1005 WP_001179707.1 IS110-like element ISSfl8 family transposase -
BE932_RS24250 4274212..4274499 + 288 Protein_4104 DUF4942 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC 4269634..4314642 45008


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14223.17 Da        Isoelectric Point: 6.7029

>T71289 WP_061091468.1 NZ_CP018991:4270058-4270435 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTLFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T71289 NZ_CP018991:4270058-4270435 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACTGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTTGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACCGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13806.71 Da        Isoelectric Point: 6.7387

>AT71289 WP_032215284.1 NZ_CP018991:4269634-4270011 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT71289 NZ_CP018991:4269634-4270011 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCAGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGTGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References