Detailed information of TA system TA071243

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2792301..2793135
• Replicon: chromosome
• Accession: NZ_CP018983
• Organism: Escherichia coli strain Ecol_867

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: S1PLF5
• Locus tag: BE928_RS15400
• Protein ID: WP_000854690.1
• Coordinates: 2792758..2793135 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: S1P7N8
• Locus tag: BE928_RS15395
• Protein ID: WP_001305076.1
• Coordinates: 2792301..2792669 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BE928_RS15350	2787383..2788510	+	1128	Protein_2686	hypothetical protein	-
BE928_RS15355	2788586..2789041	+	456	WP_000581502.1	hypothetical protein	-
BE928_RS15360	2789120..2789353	+	234	WP_000902034.1	DUF905 family protein	-
BE928_RS15370	2789454..2790272	+	819	WP_001234620.1	DUF945 domain-containing protein	-
BE928_RS15375	2790327..2790812	+	486	WP_033555267.1	antirestriction protein	-
BE928_RS15380	2790828..2791304	+	477	WP_078214997.1	RadC family protein	-
BE928_RS15385	2791367..2791588	+	222	WP_000692329.1	DUF987 domain-containing protein	-
BE928_RS15390	2791607..2792251	+	645	WP_000094916.1	hypothetical protein	-
BE928_RS15395	2792301..2792669	+	369	WP_001305076.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
BE928_RS15400	2792758..2793135	+	378	WP_000854690.1	TA system toxin CbtA family protein	Toxin
BE928_RS15405	2793132..2793620	+	489	WP_000761699.1	hypothetical protein	-
BE928_RS15410	2793637..2793834	+	198	WP_000839293.1	DUF957 domain-containing protein	-
BE928_RS15415	2793919..2794764	+	846	WP_001529401.1	DUF4942 domain-containing protein	-
BE928_RS15420	2794833..2795228	+	396	WP_000208384.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
BE928_RS15425	2795221..2796154	+	934	Protein_2700	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
BE928_RS27000	2796586..2796741	+	156	WP_000729638.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / kpsM / kpsT	2748023..2813000	64977
	-	flank	IS/Tn	-	-	2796586..2796741	155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14057.04 Da
• Isoelectric Point: 9.1510

>T71243 WP_000854690.1 NZ_CP018983:2792758-2793135 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

>T71243 NZ_CP018983:2792758-2793135 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13560.39 Da
• Isoelectric Point: 4.7830

>AT71243 WP_001305076.1 NZ_CP018983:2792301-2792669 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN

Nucleotide

• Length: 369 bp

>AT71243 NZ_CP018983:2792301-2792669 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Toxin

• AlphaFold DB: S1PLF5

Antitoxin

• AlphaFold DB: S1P7N8