Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1715570..1716401 Replicon chromosome
Accession NZ_CP018983
Organism Escherichia coli strain Ecol_867

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag BE928_RS10160 Protein ID WP_000854815.1
Coordinates 1716027..1716401 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag BE928_RS10155 Protein ID WP_001280918.1
Coordinates 1715570..1715938 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE928_RS10105 1710976..1711326 - 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
BE928_RS10110 1711323..1711748 - 426 WP_000422741.1 IS66 family insertion sequence hypothetical protein -
BE928_RS10115 1711854..1712264 + 411 WP_000846703.1 hypothetical protein -
BE928_RS10125 1712485..1713303 + 819 WP_001542275.1 DUF945 domain-containing protein -
BE928_RS10130 1713303..1713548 + 246 WP_001164966.1 hypothetical protein -
BE928_RS10135 1713642..1714115 + 474 WP_001542276.1 antirestriction protein -
BE928_RS10140 1714131..1714607 + 477 WP_001186200.1 RadC family protein -
BE928_RS10145 1714670..1714891 + 222 WP_000692345.1 DUF987 domain-containing protein -
BE928_RS10150 1714910..1715554 + 645 WP_000086752.1 hypothetical protein -
BE928_RS10155 1715570..1715938 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BE928_RS10160 1716027..1716401 + 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
BE928_RS10165 1716398..1716592 + 195 WP_000988600.1 hypothetical protein -
BE928_RS26550 1716605..1716718 + 114 WP_001161660.1 DUF957 domain-containing protein -
BE928_RS10170 1717007..1717153 - 147 Protein_1731 transposase domain-containing protein -
BE928_RS10175 1717207..1717389 + 183 WP_001296208.1 hypothetical protein -
BE928_RS10180 1717490..1717819 - 330 WP_000450409.1 DUF496 family protein -
BE928_RS10185 1717991..1719049 - 1059 WP_001200889.1 FUSC family protein -
BE928_RS10190 1719247..1719720 - 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
BE928_RS10195 1719839..1721005 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T71240 WP_000854815.1 NZ_CP018983:1716027-1716401 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T71240 NZ_CP018983:1716027-1716401 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT71240 WP_001280918.1 NZ_CP018983:1715570-1715938 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT71240 NZ_CP018983:1715570-1715938 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References