Detailed information of TA system TA071197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 2854650..2855470
• Replicon: chromosome
• Accession: NZ_CP018979
• Organism: Escherichia coli strain Ecol_656

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: BE941_RS15655
• Protein ID: WP_001054379.1
• Coordinates: 2855213..2855470 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: BE941_RS15650
• Protein ID: WP_000123957.1
• Coordinates: 2854650..2855201 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BE941_RS15620	2850344..2851657	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
BE941_RS15625	2851669..2851947	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
BE941_RS15630	2851944..2853065	-	1122	WP_000010833.1	M42 family metallopeptidase	-
BE941_RS28935	2853310..2853426	-	117	Protein_2654	VOC family protein	-
BE941_RS15640	2853464..2853724	-	261	WP_000077645.1	hypothetical protein	-
BE941_RS15645	2853852..2854598	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
BE941_RS15650	2854650..2855201	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
BE941_RS15655	2855213..2855470	-	258	WP_001054379.1	YjhX family toxin	Toxin
BE941_RS15660	2855847..2856011	-	165	Protein_2659	GNAT family N-acetyltransferase	-
BE941_RS15670	2857254..2858360	+	1107	Protein_2661	helicase YjhR	-
BE941_RS15680	2858943..2859923	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T71197 WP_001054379.1 NZ_CP018979:c2855470-2855213 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T71197 NZ_CP018979:c2855470-2855213 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT71197 WP_000123957.1 NZ_CP018979:c2855201-2854650 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT71197 NZ_CP018979:c2855201-2854650 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030