71185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 40920..41751 Replicon chromosome
Accession NZ_CP018979
Organism Escherichia coli strain Ecol_656

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag BE941_RS01455 Protein ID WP_000854815.1
Coordinates 41377..41751 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag BE941_RS01450 Protein ID WP_001280918.1
Coordinates 40920..41288 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE941_RS01400 36009..36755 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
BE941_RS01405 36838..37188 + 351 Protein_54 hypothetical protein -
BE941_RS01410 37204..37614 + 411 WP_000846703.1 hypothetical protein -
BE941_RS01420 37835..38653 + 819 WP_001542275.1 DUF945 domain-containing protein -
BE941_RS01425 38653..38898 + 246 WP_001164966.1 hypothetical protein -
BE941_RS01430 38992..39465 + 474 WP_001542276.1 antirestriction protein -
BE941_RS01435 39481..39957 + 477 WP_001186200.1 RadC family protein -
BE941_RS01440 40020..40241 + 222 WP_000692345.1 DUF987 domain-containing protein -
BE941_RS01445 40260..40904 + 645 WP_000086752.1 hypothetical protein -
BE941_RS01450 40920..41288 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BE941_RS01455 41377..41751 + 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
BE941_RS01460 41748..41942 + 195 WP_000988600.1 hypothetical protein -
BE941_RS28440 41955..42068 + 114 WP_001161660.1 DUF957 domain-containing protein -
BE941_RS01465 42357..42503 - 147 Protein_66 transposase domain-containing protein -
BE941_RS01470 42557..42739 + 183 WP_001296208.1 hypothetical protein -
BE941_RS01475 42840..43169 - 330 WP_000450409.1 DUF496 family protein -
BE941_RS01480 43341..44399 - 1059 WP_001200889.1 FUSC family protein -
BE941_RS01485 44597..45070 - 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
BE941_RS01490 45189..46355 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T71185 WP_000854815.1 NZ_CP018979:41377-41751 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T71185 NZ_CP018979:41377-41751 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT71185 WP_001280918.1 NZ_CP018979:40920-41288 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT71185 NZ_CP018979:40920-41288 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References