Detailed information of TA system TA071027

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3330899..3331719
• Replicon: chromosome
• Accession: NZ_CP018953
• Organism: Escherichia coli strain Ecol_276

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: BE964_RS18675
• Protein ID: WP_001054379.1
• Coordinates: 3331462..3331719 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: BE964_RS18670
• Protein ID: WP_000123957.1
• Coordinates: 3330899..3331450 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BE964_RS18640	3326593..3327906	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
BE964_RS18645	3327918..3328196	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
BE964_RS18650	3328193..3329314	-	1122	WP_000010833.1	M42 family metallopeptidase	-
BE964_RS27640	3329559..3329675	-	117	Protein_3127	VOC family protein	-
BE964_RS18660	3329713..3329973	-	261	WP_000077645.1	hypothetical protein	-
BE964_RS18665	3330101..3330847	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
BE964_RS18670	3330899..3331450	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
BE964_RS18675	3331462..3331719	-	258	WP_001054379.1	YjhX family toxin	Toxin
BE964_RS18680	3332096..3332260	-	165	Protein_3132	GNAT family N-acetyltransferase	-
BE964_RS18690	3333503..3334609	+	1107	Protein_3134	helicase YjhR	-
BE964_RS18700	3335192..3336172	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T71027 WP_001054379.1 NZ_CP018953:c3331719-3331462 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T71027 NZ_CP018953:c3331719-3331462 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT71027 WP_000123957.1 NZ_CP018953:c3331450-3330899 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT71027 NZ_CP018953:c3331450-3330899 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030