Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2976521..2977496 Replicon chromosome
Accession NZ_CP018931
Organism Bacillus cereus strain ISSFR-3F

Toxin (Protein)


Gene name spoIISA Uniprot ID C3GJ28
Locus tag BEI48_RS16170 Protein ID WP_003297560.1
Coordinates 2976759..2977496 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag BEI48_RS16165 Protein ID WP_000588712.1
Coordinates 2976521..2976646 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BEI48_RS16125 2972314..2972784 + 471 WP_029438359.1 DUF5065 family protein -
BEI48_RS16135 2973311..2974780 - 1470 WP_000287522.1 beta-Ala-His dipeptidase -
BEI48_RS29545 2974924..2975100 - 177 WP_000808046.1 hypothetical protein -
BEI48_RS16150 2975439..2975675 + 237 WP_001021688.1 hypothetical protein -
BEI48_RS16155 2975952..2976233 + 282 WP_001041554.1 hypothetical protein -
BEI48_RS16165 2976521..2976646 - 126 WP_000588712.1 hypothetical protein Antitoxin
BEI48_RS16170 2976759..2977496 - 738 WP_003297560.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BEI48_RS16180 2977685..2978422 - 738 WP_000594156.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BEI48_RS16185 2978590..2979072 - 483 WP_000191912.1 MarR family winged helix-turn-helix transcriptional regulator -
BEI48_RS16190 2979179..2980864 + 1686 WP_003304987.1 alpha-keto acid decarboxylase family protein -
BEI48_RS29550 2980986..2981078 - 93 Protein_3004 methyltransferase -
BEI48_RS16195 2981184..2981591 - 408 WP_000072480.1 VOC family protein -
BEI48_RS16200 2981711..2982371 - 661 Protein_3006 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.07 Da        Isoelectric Point: 8.2672

>T70953 WP_003297560.1 NZ_CP018931:c2977496-2976759 [Bacillus cereus]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T70953 NZ_CP018931:c2977496-2976759 [Bacillus cereus]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAATACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT70953 WP_000588712.1 NZ_CP018931:c2976646-2976521 [Bacillus cereus]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT70953 NZ_CP018931:c2976646-2976521 [Bacillus cereus]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9EK80

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References