Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3614930..3615599 Replicon chromosome
Accession NZ_CP018930
Organism Serratia marcescens strain UMH12

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag BVG84_RS17350 Protein ID WP_025304123.1
Coordinates 3614930..3615352 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag BVG84_RS17355 Protein ID WP_004931679.1
Coordinates 3615333..3615599 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG84_RS17330 3610819..3611337 + 519 WP_025304119.1 flavodoxin FldB -
BVG84_RS17335 3611375..3612739 - 1365 WP_025304120.1 cell envelope integrity protein CreD -
BVG84_RS17340 3612820..3614238 - 1419 WP_043142606.1 two-component system sensor histidine kinase CreC -
BVG84_RS17345 3614235..3614930 - 696 WP_025304122.1 two-component system response regulator CreB -
BVG84_RS17350 3614930..3615352 - 423 WP_025304123.1 protein YgfX Toxin
BVG84_RS17355 3615333..3615599 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
BVG84_RS17360 3615920..3616912 + 993 WP_060448422.1 tRNA-modifying protein YgfZ -
BVG84_RS17365 3616951..3617448 - 498 WP_025304125.1 DUF2165 domain-containing protein -
BVG84_RS17370 3617599..3618273 - 675 WP_033639467.1 hemolysin III family protein -
BVG84_RS17375 3618457..3619065 + 609 WP_025304127.1 HD domain-containing protein -
BVG84_RS17380 3619105..3620031 - 927 WP_025304128.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16525.62 Da        Isoelectric Point: 10.8432

>T70951 WP_025304123.1 NZ_CP018930:c3615352-3614930 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGYGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGLLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGNGEEP

Download         Length: 423 bp

>T70951 NZ_CP018930:c3615352-3614930 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTTTTTTCCCTGTTGACTCATGGCGTTCTGATCTT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGTTATGGCCCGCTTTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGTAGCCAGAAGCGCATCGCCGCAGTGCAGGGCGAGCTGCGGCTGCTGGCGGACCGGCGTTTCAGCTGGCACGGCCGA
GAATGGCGGCTGGCGAAAAAGCCCTGGATGCCGGGCTACGGCCTGCTGCTGACGCTGCAGCCGATGGAAGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTAACGGCGAGGAACCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT70951 WP_004931679.1 NZ_CP018930:c3615599-3615333 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT70951 NZ_CP018930:c3615599-3615333 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References