Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH
Location 3606556..3607279 Replicon chromosome
Accession NZ_CP018930
Organism Serratia marcescens strain UMH12

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BVG84_RS17305 Protein ID WP_049296187.1
Coordinates 3606556..3606942 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag BVG84_RS17310 Protein ID WP_025304117.1
Coordinates 3606935..3607279 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG84_RS17285 3601935..3603245 + 1311 WP_060448423.1 MFS transporter -
BVG84_RS17295 3603669..3605186 - 1518 WP_004931697.1 lysine--tRNA ligase -
BVG84_RS17305 3606556..3606942 + 387 WP_049296187.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BVG84_RS17310 3606935..3607279 + 345 WP_025304117.1 helix-turn-helix domain-containing protein Antitoxin
BVG84_RS17315 3607330..3609063 - 1734 WP_016929971.1 single-stranded-DNA-specific exonuclease RecJ -
BVG84_RS17320 3609070..3609786 - 717 WP_025304118.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BVG84_RS17325 3609813..3610733 - 921 WP_154747450.1 site-specific tyrosine recombinase XerD -
BVG84_RS17330 3610819..3611337 + 519 WP_025304119.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(54-91)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14614.65 Da        Isoelectric Point: 9.4235

>T70950 WP_049296187.1 NZ_CP018930:3606556-3606942 [Serratia marcescens]
MDIFVTDDFDKFMKKNRIVDQKICTAAHELAHGNHDGDLGGGVYKKRISLNRGKRGGARSIVAFKRGRHQYFIDGWLKNT
VKQNGAKEINDDELATYRELARDFLAMPPEIIKRAIDSGYLREVKCDD

Download         Length: 387 bp

>T70950 NZ_CP018930:3606556-3606942 [Serratia marcescens]
ATGGACATTTTCGTCACGGATGATTTCGACAAATTTATGAAGAAAAATCGCATCGTCGATCAAAAGATTTGCACCGCGGC
TCACGAACTCGCACACGGTAACCATGACGGCGATCTGGGCGGCGGCGTCTACAAGAAACGTATTTCGCTCAATCGGGGTA
AACGGGGTGGCGCTCGATCCATCGTGGCGTTTAAACGCGGTCGTCATCAGTATTTTATTGATGGATGGCTGAAAAACACC
GTAAAACAGAACGGTGCAAAAGAAATCAACGATGATGAATTGGCAACCTATCGCGAGCTCGCCAGAGATTTTCTTGCCAT
GCCGCCGGAAATTATCAAACGAGCCATCGATAGCGGCTACTTGCGAGAGGTGAAATGCGATGACTGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12919.85 Da        Isoelectric Point: 11.4121

>AT70950 WP_025304117.1 NZ_CP018930:3606935-3607279 [Serratia marcescens]
MTDNRLLRLQKMAQRFNEIGAVSDDTVRNIATRVQAQEQHAQREQHDQMDGARIKMLRRRLGLSQADLAAVVNMSTTSVQ
KWERNAVKPQGAALRMLEIIEQKGVASLIISPRN

Download         Length: 345 bp

>AT70950 NZ_CP018930:3606935-3607279 [Serratia marcescens]
ATGACTGATAATCGCCTGCTCAGACTGCAAAAAATGGCACAGCGTTTTAATGAGATCGGTGCGGTGTCAGACGATACCGT
ACGCAACATCGCCACACGAGTACAGGCGCAGGAACAACATGCCCAGCGTGAGCAGCATGATCAAATGGACGGCGCACGCA
TCAAAATGCTGCGCAGACGGCTCGGCCTGAGCCAGGCCGATTTAGCGGCCGTGGTCAACATGTCGACCACCAGCGTACAA
AAATGGGAACGTAACGCGGTAAAACCCCAGGGAGCCGCGCTCAGAATGCTGGAAATTATCGAACAGAAAGGGGTCGCCAG
CCTGATCATCTCACCACGAAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References