Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 866320..866867 Replicon chromosome
Accession NZ_CP018930
Organism Serratia marcescens strain UMH12

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag BVG84_RS04295 Protein ID WP_049208872.1
Coordinates 866559..866867 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag BVG84_RS04290 Protein ID WP_025302143.1
Coordinates 866320..866556 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG84_RS04275 862806..864341 + 1536 WP_060447542.1 glutathione ABC transporter substrate-binding protein GsiB -
BVG84_RS04280 864394..865314 + 921 WP_060447541.1 glutathione ABC transporter permease GsiC -
BVG84_RS04285 865324..866232 + 909 WP_169540348.1 glutathione ABC transporter permease GsiD -
BVG84_RS04290 866320..866556 + 237 WP_025302143.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
BVG84_RS04295 866559..866867 + 309 WP_049208872.1 CcdB family protein Toxin
BVG84_RS04300 866907..867749 - 843 WP_015377214.1 S-formylglutathione hydrolase -
BVG84_RS04305 867764..868888 - 1125 WP_016928454.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
BVG84_RS04310 868919..869839 - 921 WP_060447540.1 LysR family transcriptional regulator -
BVG84_RS04315 869945..871102 + 1158 WP_060447539.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11518.35 Da        Isoelectric Point: 5.0196

>T70938 WP_049208872.1 NZ_CP018930:866559-866867 [Serratia marcescens]
MQFTVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAIRISQIGKA
VGNVNEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

>T70938 NZ_CP018930:866559-866867 [Serratia marcescens]
ATGCAATTTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGTCCTCTCGACCCGGTTAATGATCCCCCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGG
AGATTGAGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCATACGTATTTCGCAGATTGGGAAGGCC
GTTGGTAATGTCAATGAGCACAGGAATCAAATTAAAGCCGCTATCGATTTTCTGATTGATGGCTTTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8967.04 Da        Isoelectric Point: 5.0807

>AT70938 WP_025302143.1 NZ_CP018930:866320-866556 [Serratia marcescens]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT70938 NZ_CP018930:866320-866556 [Serratia marcescens]
ATGGCAAATAGCAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCCGTATTGACGGACGCATTGAGCGTCCGCGTCAGGGATATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGCGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References