Detailed information of TA system TA070930

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3133802..3134458
• Replicon: chromosome
• Accession: NZ_CP018929
• Organism: Serratia marcescens strain UMH11

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A656VD00
• Locus tag: BVG89_RS14945
• Protein ID: WP_025303864.1
• Coordinates: 3133802..3134191 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8G2LCA8
• Locus tag: BVG89_RS14950
• Protein ID: WP_004941563.1
• Coordinates: 3134195..3134458 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVG89_RS14930	3130281..3131699	+	1419	WP_089181208.1	multidrug transporter subunit MdtD	-
BVG89_RS14935	3131696..3133078	+	1383	WP_049204856.1	two-component system sensor histidine kinase BaeS	-
BVG89_RS14940	3133078..3133794	+	717	WP_004941568.1	two-component system response regulator BaeR	-
BVG89_RS14945	3133802..3134191	-	390	WP_025303864.1	type II toxin-antitoxin system VapC family toxin	Toxin
BVG89_RS14950	3134195..3134458	-	264	WP_004941563.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
BVG89_RS14955	3134796..3135134	+	339	WP_016926703.1	YegP family protein	-
BVG89_RS14960	3135313..3136665	+	1353	WP_025303865.1	tRNA 5-hydroxyuridine modification protein YegQ	-
BVG89_RS24825	3136882..3137103	-	222	WP_141998673.1	hypothetical protein	-
BVG89_RS14965	3137133..3138038	+	906	WP_043137977.1	lipid kinase YegS	-
BVG89_RS14970	3138207..3139421	+	1215	WP_049296104.1	D-galactonate dehydratase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14351.67 Da
• Isoelectric Point: 9.5570

>T70930 WP_025303864.1 NZ_CP018929:c3134191-3133802 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMQKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDREAARCYGEM
RANMGRKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Nucleotide

• Length: 390 bp

>T70930 NZ_CP018929:c3134191-3133802 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGCAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCCAAACGGCGGAACAAAGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCGGTGACGGTCTATGCATGGGATCGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGGGCAAACATGGGGAGAAAGGGCAAAATCATGGGCGCGATGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10062.31 Da
• Isoelectric Point: 4.6702

>AT70930 WP_004941563.1 NZ_CP018929:c3134458-3134195 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Nucleotide

• Length: 264 bp

>AT70930 NZ_CP018929:c3134458-3134195 [Serratia marcescens]
ATGGAAAGAATCGCCAAGCTGTTTAAAAACGGTAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTGTATATCCGTCGCGATCGGGAGGGAAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Structures

Toxin

• AlphaFold DB: A0A656VD00