Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH
Location 3484431..3485154 Replicon chromosome
Accession NZ_CP018928
Organism Serratia marcescens strain UMH10

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BVG92_RS16585 Protein ID WP_049296187.1
Coordinates 3484431..3484817 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag BVG92_RS16590 Protein ID WP_025304117.1
Coordinates 3484810..3485154 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG92_RS16575 3481544..3483061 - 1518 WP_004931697.1 lysine--tRNA ligase -
BVG92_RS16585 3484431..3484817 + 387 WP_049296187.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BVG92_RS16590 3484810..3485154 + 345 WP_025304117.1 helix-turn-helix domain-containing protein Antitoxin
BVG92_RS16595 3485205..3486938 - 1734 WP_016929971.1 single-stranded-DNA-specific exonuclease RecJ -
BVG92_RS16600 3486945..3487661 - 717 WP_025304118.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BVG92_RS16605 3487688..3488608 - 921 WP_154747450.1 site-specific tyrosine recombinase XerD -
BVG92_RS16610 3488694..3489212 + 519 WP_033635825.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(54-91)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14614.65 Da        Isoelectric Point: 9.4235

>T70913 WP_049296187.1 NZ_CP018928:3484431-3484817 [Serratia marcescens]
MDIFVTDDFDKFMKKNRIVDQKICTAAHELAHGNHDGDLGGGVYKKRISLNRGKRGGARSIVAFKRGRHQYFIDGWLKNT
VKQNGAKEINDDELATYRELARDFLAMPPEIIKRAIDSGYLREVKCDD

Download         Length: 387 bp

>T70913 NZ_CP018928:3484431-3484817 [Serratia marcescens]
ATGGACATTTTCGTCACGGATGATTTCGACAAATTTATGAAGAAAAATCGCATCGTCGATCAAAAGATTTGCACCGCGGC
TCACGAACTCGCACACGGTAACCATGACGGCGATCTGGGCGGCGGCGTCTACAAGAAACGTATTTCGCTCAATCGGGGTA
AACGGGGTGGCGCTCGATCCATCGTGGCGTTTAAACGCGGTCGTCATCAGTATTTTATTGATGGATGGCTGAAAAACACC
GTAAAACAGAACGGTGCAAAAGAAATCAACGATGATGAATTGGCAACCTATCGCGAGCTCGCCAGAGATTTTCTTGCCAT
GCCGCCGGAAATTATCAAACGAGCCATCGATAGCGGCTACTTGCGAGAGGTGAAATGCGATGACTGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12919.85 Da        Isoelectric Point: 11.4121

>AT70913 WP_025304117.1 NZ_CP018928:3484810-3485154 [Serratia marcescens]
MTDNRLLRLQKMAQRFNEIGAVSDDTVRNIATRVQAQEQHAQREQHDQMDGARIKMLRRRLGLSQADLAAVVNMSTTSVQ
KWERNAVKPQGAALRMLEIIEQKGVASLIISPRN

Download         Length: 345 bp

>AT70913 NZ_CP018928:3484810-3485154 [Serratia marcescens]
ATGACTGATAATCGCCTGCTCAGACTGCAAAAAATGGCACAGCGTTTTAATGAGATCGGTGCGGTGTCAGACGATACCGT
ACGCAACATCGCCACACGAGTACAGGCGCAGGAACAACATGCCCAGCGTGAGCAGCATGATCAAATGGACGGCGCACGCA
TCAAAATGCTGCGCAGACGGCTTGGCTTGAGCCAGGCCGATTTAGCGGCCGTGGTCAACATGTCGACCACCAGCGTACAA
AAATGGGAACGTAACGCGGTAAAACCCCAGGGAGCCGCGCTCAGAATGCTGGAAATTATCGAACAGAAAGGGGTCGCCAG
CCTGATCATCTCACCACGAAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References