Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3035081..3035643 Replicon chromosome
Accession NZ_CP018928
Organism Serratia marcescens strain UMH10

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag BVG92_RS14505 Protein ID WP_025303801.1
Coordinates 3035081..3035437 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag BVG92_RS14510 Protein ID WP_004936539.1
Coordinates 3035434..3035643 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG92_RS14485 3030817..3031614 - 798 WP_025303797.1 energy transducer TonB -
BVG92_RS14490 3031717..3032556 - 840 WP_025303798.1 ChaN family lipoprotein -
BVG92_RS14495 3032734..3034143 + 1410 WP_049205384.1 S-methylmethionine permease -
BVG92_RS14500 3034133..3035071 + 939 WP_089181192.1 homocysteine S-methyltransferase -
BVG92_RS14505 3035081..3035437 - 357 WP_025303801.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
BVG92_RS14510 3035434..3035643 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BVG92_RS14515 3035753..3038032 - 2280 WP_016926766.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
BVG92_RS25020 3038248..3038421 - 174 WP_049205380.1 hypothetical protein -
BVG92_RS14520 3038402..3038782 - 381 WP_025303802.1 DUF2570 family protein -
BVG92_RS14525 3038779..3039180 - 402 WP_015378690.1 M15 family metallopeptidase -
BVG92_RS14530 3039170..3039496 - 327 WP_004936551.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13163.93 Da        Isoelectric Point: 4.9139

>T70910 WP_025303801.1 NZ_CP018928:c3035437-3035081 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLTE

Download         Length: 357 bp

>T70910 NZ_CP018928:c3035437-3035081 [Serratia marcescens]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAGTTCAATGCTGAAATTGTGCCTCACGGCCGCCAGGAAGGCAGCAAAGT
TGAGGCTGTAGCCAACCGCGTGCTCAATGCTTACCACTACGAGAACGTCACAGACGTTTACCGCTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGACGCAGAACTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTTGA
ACAAGCCGCTGAACACTTACGCCGGCTAACCGAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT70910 WP_004936539.1 NZ_CP018928:c3035643-3035434 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT70910 NZ_CP018928:c3035643-3035434 [Serratia marcescens]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTTTTGGTCAAAGCCAAAGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References