Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 871887..872434 Replicon chromosome
Accession NZ_CP018928
Organism Serratia marcescens strain UMH10

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag BVG92_RS04310 Protein ID WP_049208872.1
Coordinates 872126..872434 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag BVG92_RS04305 Protein ID WP_025302143.1
Coordinates 871887..872123 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG92_RS04290 868373..869908 + 1536 WP_089180702.1 glutathione ABC transporter substrate-binding protein GsiB -
BVG92_RS04295 869961..870881 + 921 WP_025302141.1 glutathione ABC transporter permease GsiC -
BVG92_RS04300 870891..871799 + 909 WP_169540348.1 glutathione ABC transporter permease GsiD -
BVG92_RS04305 871887..872123 + 237 WP_025302143.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
BVG92_RS04310 872126..872434 + 309 WP_049208872.1 CcdB family protein Toxin
BVG92_RS04315 872474..873316 - 843 WP_015377214.1 S-formylglutathione hydrolase -
BVG92_RS04320 873331..874455 - 1125 WP_043142415.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
BVG92_RS04325 874486..875406 - 921 WP_089180703.1 LysR family transcriptional regulator -
BVG92_RS04330 875512..876669 + 1158 WP_043142422.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11518.35 Da        Isoelectric Point: 5.0196

>T70900 WP_049208872.1 NZ_CP018928:872126-872434 [Serratia marcescens]
MQFTVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAIRISQIGKA
VGNVNEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

>T70900 NZ_CP018928:872126-872434 [Serratia marcescens]
ATGCAATTTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGTCCTCTCGACCCGGTTAATGATCCCCCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGG
AGATTGAGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCATACGTATTTCGCAGATTGGGAAGGCC
GTTGGTAATGTCAATGAGCACAGGAATCAAATTAAAGCCGCTATCGATTTTCTGATTGATGGCTTTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8967.04 Da        Isoelectric Point: 5.0807

>AT70900 WP_025302143.1 NZ_CP018928:871887-872123 [Serratia marcescens]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT70900 NZ_CP018928:871887-872123 [Serratia marcescens]
ATGGCAAATAGCAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCCGTATTGACGGACGCATTGAGCGTCCGCGTCAGGGATATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGCGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References