Detailed information of TA system TA070896

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3787091..3787686
• Replicon: chromosome
• Accession: NZ_CP018927
• Organism: Serratia marcescens strain UMH8

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1S6LRI1
• Locus tag: BVG90_RS18110
• Protein ID: WP_071605322.1
• Coordinates: 3787432..3787686 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: BVG90_RS18105
• Protein ID: WP_063988754.1
• Coordinates: 3787091..3787432 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVG90_RS18090	3782778..3784550	+	1773	WP_089185051.1	terminase ATPase subunit family protein	-
BVG90_RS18095	3784550..3785584	+	1035	WP_089185052.1	phage portal protein	-
BVG90_RS18100	3785615..3786925	-	1311	WP_089185053.1	DUF3644 domain-containing protein	-
BVG90_RS18105	3787091..3787432	-	342	WP_063988754.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BVG90_RS18110	3787432..3787686	-	255	WP_071605322.1	type II toxin-antitoxin system HicA family toxin	Toxin
BVG90_RS18115	3788102..3789307	-	1206	WP_089185054.1	chromate efflux transporter	-
BVG90_RS18120	3789434..3789631	-	198	WP_145957367.1	hypothetical protein	-
BVG90_RS18125	3789679..3789903	-	225	WP_089185056.1	hypothetical protein	-
BVG90_RS18130	3789942..3792152	-	2211	WP_089185057.1	replication endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3758071..3797871	39800

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (55-100)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9495.97 Da
• Isoelectric Point: 11.1073

>T70896 WP_071605322.1 NZ_CP018927:c3787686-3787432 [Serratia marcescens]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Nucleotide

• Length: 255 bp

>T70896 NZ_CP018927:c3787686-3787432 [Serratia marcescens]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTGCCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAGGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCCATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12390.89 Da
• Isoelectric Point: 4.4537

>AT70896 WP_063988754.1 NZ_CP018927:c3787432-3787091 [Serratia marcescens]
MNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECQKDGIEPYKSYSGKVTTRLSP
ERHQALALAAQATGQSINELLNEGVDLVIEKHS

Nucleotide

• Length: 342 bp

>AT70896 NZ_CP018927:c3787432-3787091 [Serratia marcescens]
ATGAATAATACACTGAAAATTGACGGCCATACGGCCGTCATCAACTTTGACCCTGAAATTGAAATGTTCCGGGGCGAGTT
TGTCGGGCTGAACGGCGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGATCTCACTCGCGG
TCTTTCTCGATGAGTGCCAAAAAGACGGCATCGAGCCCTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCGCCG
GAACGCCATCAGGCGCTAGCCCTTGCCGCACAGGCCACCGGGCAGTCGATTAACGAGCTGCTGAATGAAGGCGTTGATTT
AGTTATCGAAAAACACTCATGA

Structures

Toxin

• AlphaFold DB: A0A1S6LRI1