Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 411471..412092 Replicon chromosome
Accession NZ_CP018927
Organism Serratia marcescens strain UMH8

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag BVG90_RS01950 Protein ID WP_004940313.1
Coordinates 411471..411674 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag BVG90_RS01955 Protein ID WP_004940312.1
Coordinates 411724..412092 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG90_RS01920 407171..407509 + 339 WP_004940327.1 P-II family nitrogen regulator -
BVG90_RS01925 407545..408831 + 1287 WP_004940322.1 ammonium transporter AmtB -
BVG90_RS01930 408922..409785 - 864 WP_016928847.1 acyl-CoA thioesterase II -
BVG90_RS01935 410016..410507 + 492 WP_016928846.1 YbaY family lipoprotein -
BVG90_RS01940 410572..410886 - 315 WP_004940317.1 MGMT family protein -
BVG90_RS01950 411471..411674 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
BVG90_RS01955 411724..412092 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
BVG90_RS01960 412251..412604 - 354 WP_048795900.1 hypothetical protein -
BVG90_RS01970 413009..413722 + 714 WP_033641138.1 ABC transporter ATP-binding protein -
BVG90_RS01975 413719..414576 + 858 WP_004940309.1 metal ABC transporter permease -
BVG90_RS01980 414602..415480 + 879 WP_016928843.1 metal ABC transporter substrate-binding protein -
BVG90_RS01985 415588..415728 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
BVG90_RS01990 415741..415995 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T70884 WP_004940313.1 NZ_CP018927:c411674-411471 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T70884 NZ_CP018927:c411674-411471 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTTTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT70884 WP_004940312.1 NZ_CP018927:c412092-411724 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT70884 NZ_CP018927:c412092-411724 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGGCACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTATGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References