Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4704616..4705151 Replicon chromosome
Accession NZ_CP018925
Organism Serratia marcescens strain UMH3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BVG91_RS22585 Protein ID WP_033649525.1
Coordinates 4704876..4705151 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag BVG91_RS22580 Protein ID WP_033649526.1
Coordinates 4704616..4704876 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG91_RS22560 4699935..4700585 + 651 WP_033649530.1 DcrB-related protein -
BVG91_RS22565 4700626..4701231 + 606 WP_089187532.1 glutathione S-transferase -
BVG91_RS22570 4701301..4702695 + 1395 WP_033649528.1 L-seryl-tRNA(Sec) selenium transferase -
BVG91_RS22575 4702692..4704533 + 1842 WP_033649527.1 selenocysteine-specific translation elongation factor -
BVG91_RS22580 4704616..4704876 + 261 WP_033649526.1 ribbon-helix-helix domain-containing protein Antitoxin
BVG91_RS22585 4704876..4705151 + 276 WP_033649525.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BVG91_RS22590 4705163..4706074 - 912 WP_033636572.1 LysR family transcriptional regulator -
BVG91_RS22595 4706196..4706822 + 627 WP_033649524.1 LysE family translocator -
BVG91_RS22600 4706876..4708123 - 1248 WP_043148337.1 MFS transporter -
BVG91_RS22605 4708341..4709333 + 993 WP_049213612.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10596.34 Da        Isoelectric Point: 10.3377

>T70883 WP_033649525.1 NZ_CP018925:4704876-4705151 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALVNRTAAANSVKALVAAPKALLDNSRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Download         Length: 276 bp

>T70883 NZ_CP018925:4704876-4705151 [Serratia marcescens]
ATGGAGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGTTAACCGTACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATTCTCGCCTGGGTGAAAGACTGGACG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9698.01 Da        Isoelectric Point: 4.5201

>AT70883 WP_033649526.1 NZ_CP018925:4704616-4704876 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALTAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp

>AT70883 NZ_CP018925:4704616-4704876 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTCCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
CTCACGGGGATGGATAGTGAAGCAAGCCCTCACCGCCTGGCTCGAGCAAGAGGAAGAGCGTCGTCGGTTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAATCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References