Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4663683..4664284 Replicon chromosome
Accession NZ_CP018925
Organism Serratia marcescens strain UMH3

Toxin (Protein)


Gene name vapC Uniprot ID A0A2V4FS51
Locus tag BVG91_RS22405 Protein ID WP_033649548.1
Coordinates 4663683..4664063 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2S4X5L5
Locus tag BVG91_RS22410 Protein ID WP_039568270.1
Coordinates 4664063..4664284 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG91_RS22380 4658936..4660216 + 1281 WP_033649550.1 DUF3748 domain-containing protein -
BVG91_RS22385 4660247..4660594 - 348 WP_033636538.1 YceK/YidQ family lipoprotein -
BVG91_RS22390 4660905..4661318 + 414 WP_004933919.1 heat shock chaperone IbpA -
BVG91_RS22395 4661419..4661847 + 429 WP_004933922.1 heat shock chaperone IbpB -
BVG91_RS22400 4662014..4663672 + 1659 WP_033649549.1 putative transporter -
BVG91_RS22405 4663683..4664063 - 381 WP_033649548.1 type II toxin-antitoxin system VapC family toxin Toxin
BVG91_RS22410 4664063..4664284 - 222 WP_039568270.1 ribbon-helix-helix protein, CopG family Antitoxin
BVG91_RS22415 4664360..4665610 - 1251 WP_060388266.1 valine--pyruvate transaminase -
BVG91_RS22420 4665746..4667809 - 2064 WP_060388267.1 alpha-amylase -
BVG91_RS25875 4668006..4668158 + 153 WP_019455508.1 hypothetical protein -
BVG91_RS22425 4668160..4669137 - 978 WP_039568262.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14171.50 Da        Isoelectric Point: 7.3170

>T70882 WP_033649548.1 NZ_CP018925:c4664063-4663683 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIVWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T70882 NZ_CP018925:c4664063-4663683 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGTTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTGTCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTATCGGCTGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4791

>AT70882 WP_039568270.1 NZ_CP018925:c4664284-4664063 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHIPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp

>AT70882 NZ_CP018925:c4664284-4664063 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACATTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FS51

Antitoxin

Source ID Structure
AlphaFold DB A0A2S4X5L5

References