Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE(toxin)
Location 4262210..4262775 Replicon chromosome
Accession NZ_CP018925
Organism Serratia marcescens strain UMH3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BVG91_RS20625 Protein ID WP_060427174.1
Coordinates 4262497..4262775 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag BVG91_RS20620 Protein ID WP_033654862.1
Coordinates 4262210..4262479 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG91_RS20605 4258476..4259693 - 1218 WP_089187505.1 aspartate aminotransferase family protein -
BVG91_RS20610 4259825..4260400 - 576 WP_033654864.1 aminodeoxychorismate synthase component II -
BVG91_RS20615 4260473..4261999 - 1527 WP_039569209.1 DUF853 family protein -
BVG91_RS20620 4262210..4262479 + 270 WP_033654862.1 hypothetical protein Antitoxin
BVG91_RS20625 4262497..4262775 + 279 WP_060427174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BVG91_RS20630 4262776..4263501 - 726 WP_060437055.1 two-component system response regulator BtsR -
BVG91_RS20635 4263501..4265185 - 1685 Protein_4055 sensor histidine kinase -
BVG91_RS20640 4265342..4265911 - 570 WP_033636286.1 peptidylprolyl isomerase A -
BVG91_RS20650 4266265..4266603 + 339 WP_033638609.1 PTS lactose/cellobiose transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10206.83 Da        Isoelectric Point: 10.0357

>T70881 WP_060427174.1 NZ_CP018925:4262497-4262775 [Serratia marcescens]
VKLTWTEPAIADRLAIYEWLELKNPAAAAENDAKIADAAARLVHHPASGKTGRIAGTRELVISPSYLLAYEWAAQRVIVL
VIVHTRRRWPPA

Download         Length: 279 bp

>T70881 NZ_CP018925:4262497-4262775 [Serratia marcescens]
GTGAAACTGACATGGACGGAACCCGCCATCGCCGATCGTCTGGCGATTTATGAATGGTTGGAACTTAAAAATCCGGCCGC
CGCCGCAGAAAATGATGCAAAAATCGCTGACGCGGCGGCACGCCTCGTGCATCATCCCGCCAGCGGGAAAACGGGGCGGA
TAGCCGGTACGCGCGAGCTGGTCATCTCCCCGTCCTATTTGCTGGCCTATGAATGGGCGGCTCAACGCGTCATCGTATTG
GTCATCGTGCATACTCGCCGTCGGTGGCCGCCGGCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10306.54 Da        Isoelectric Point: 6.4086

>AT70881 WP_033654862.1 NZ_CP018925:4262210-4262479 [Serratia marcescens]
MSESTVVIRVDEELKTAFASAAKAADRTASQLLRDFMREFVSRQAQQEEYNQWLKEKVEVSRKALREGKFADDEEVAAYF
AERRAKSTR

Download         Length: 270 bp

>AT70881 NZ_CP018925:4262210-4262479 [Serratia marcescens]
ATGTCTGAATCTACCGTGGTAATCCGCGTGGATGAAGAGTTAAAAACCGCTTTCGCCAGCGCGGCAAAGGCCGCCGATCG
CACGGCTTCGCAACTGCTGCGTGATTTCATGCGCGAGTTTGTCAGCCGCCAGGCGCAACAGGAAGAGTACAACCAGTGGT
TAAAGGAAAAGGTCGAGGTAAGCCGCAAGGCGTTGCGTGAAGGCAAATTCGCCGACGATGAAGAGGTGGCCGCTTATTTC
GCCGAACGCAGAGCCAAATCAACGCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References