Detailed information of TA system TA070880

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3705589..3706258
• Replicon: chromosome
• Accession: NZ_CP018925
• Organism: Serratia marcescens strain UMH3

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A2V4FX75
• Locus tag: BVG91_RS18000
• Protein ID: WP_033649453.1
• Coordinates: 3705589..3706011 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8G2G4M4
• Locus tag: BVG91_RS18005
• Protein ID: WP_004931679.1
• Coordinates: 3705992..3706258 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVG91_RS17980	3701478..3701996	+	519	WP_033635825.1	flavodoxin FldB	-
BVG91_RS17985	3702034..3703398	-	1365	WP_089187460.1	cell envelope integrity protein CreD	-
BVG91_RS17990	3703479..3704897	-	1419	WP_033649455.1	two-component system sensor histidine kinase CreC	-
BVG91_RS17995	3704894..3705589	-	696	WP_049232287.1	two-component system response regulator CreB	-
BVG91_RS18000	3705589..3706011	-	423	WP_033649453.1	protein YgfX	Toxin
BVG91_RS18005	3705992..3706258	-	267	WP_004931679.1	FAD assembly factor SdhE	Antitoxin
BVG91_RS18010	3706579..3707571	+	993	WP_033649452.1	tRNA-modifying protein YgfZ	-
BVG91_RS18015	3707610..3708107	-	498	WP_033649451.1	DUF2165 domain-containing protein	-
BVG91_RS18020	3708258..3708932	-	675	WP_033649450.1	hemolysin III family protein	-
BVG91_RS18025	3709116..3709724	+	609	WP_089187461.1	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16471.59 Da
• Isoelectric Point: 10.8114

>T70880 WP_033649453.1 NZ_CP018925:c3706011-3705589 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAAQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLLPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEDP

Nucleotide

• Length: 423 bp

>T70880 NZ_CP018925:c3706011-3705589 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTGTTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGTTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGCGCAGGGCGAGCTGCGGCTGCTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCTGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAGGATCCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10387.89 Da
• Isoelectric Point: 4.7921

>AT70880 WP_004931679.1 NZ_CP018925:c3706258-3705992 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT70880 NZ_CP018925:c3706258-3705992 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGAATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAGTACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: A0A2V4FX75