Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1041948..1042473 Replicon chromosome
Accession NZ_CP018925
Organism Serratia marcescens strain UMH3

Toxin (Protein)


Gene name relE Uniprot ID A0A2S4XEJ2
Locus tag BVG91_RS05020 Protein ID WP_033654647.1
Coordinates 1041948..1042232 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B4GIN1
Locus tag BVG91_RS05025 Protein ID WP_004928423.1
Coordinates 1042222..1042473 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG91_RS04995 1037208..1038341 + 1134 WP_033637812.1 putrescine ABC transporter ATP-binding subunit PotG -
BVG91_RS05000 1038366..1039328 + 963 WP_033646669.1 putrescine ABC transporter permease PotH -
BVG91_RS05005 1039325..1040170 + 846 WP_016928360.1 putrescine ABC transporter permease PotI -
BVG91_RS05010 1040275..1040754 + 480 WP_048321404.1 YbjO family protein -
BVG91_RS05015 1040824..1041951 + 1128 WP_089187068.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
BVG91_RS05020 1041948..1042232 - 285 WP_033654647.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BVG91_RS05025 1042222..1042473 - 252 WP_004928423.1 prevent-host-death protein Antitoxin
BVG91_RS05030 1042575..1043309 - 735 WP_060445622.1 arginine ABC transporter substrate-binding protein -
BVG91_RS05035 1043509..1044177 - 669 WP_033637817.1 arginine ABC transporter permease ArtM -
BVG91_RS05040 1044177..1044893 - 717 WP_033637818.1 arginine ABC transporter permease ArtQ -
BVG91_RS05045 1044903..1045634 - 732 WP_033637819.1 arginine ABC transporter substrate-binding protein -
BVG91_RS05050 1045667..1046395 - 729 WP_038884338.1 arginine ABC transporter ATP-binding protein ArtP -
BVG91_RS05055 1046667..1047209 - 543 WP_033637821.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10817.97 Da        Isoelectric Point: 10.6941

>T70867 WP_033654647.1 NZ_CP018925:c1042232-1041948 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLVSVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Download         Length: 285 bp

>T70867 NZ_CP018925:c1042232-1041948 [Serratia marcescens]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGTATCGGTATTGGTTAATCCCCACGTCCCCGCCAACAAACTCGCCGGTTTGCCCGATTGCTACAAAATCA
AACTCAGAGCATCAGGCTTTCGTTTGGTGTATCGCGTCATGGAAACGGAGATCGTGGTTCTGGTCCTGTCAGTGGGCAAA
CGCGAACGTTCAGCGGCTTACACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9108.39 Da        Isoelectric Point: 4.5203

>AT70867 WP_004928423.1 NZ_CP018925:c1042473-1042222 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Download         Length: 252 bp

>AT70867 NZ_CP018925:c1042473-1042222 [Serratia marcescens]
ATGACGGTTCAACCCATTCTTGCCGATTCCGCAGTCAGCATCAGCGATTTTAAGAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAGCCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCACCGGAAACCTGGGAGGCTA
TCGCGGAGTACCTGGAAGATATCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4XEJ2

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GIN1

References