Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 413941..414562 Replicon chromosome
Accession NZ_CP018925
Organism Serratia marcescens strain UMH3

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag BVG91_RS01960 Protein ID WP_004940313.1
Coordinates 413941..414144 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag BVG91_RS01965 Protein ID WP_004940312.1
Coordinates 414194..414562 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG91_RS01935 409732..410178 + 447 WP_039566985.1 type II secretion system protein M -
BVG91_RS01940 410215..411030 + 816 WP_048321316.1 A24 family peptidase -
BVG91_RS01945 411027..411389 - 363 WP_033647278.1 type II secretion system pilot lipoprotein GspS -
BVG91_RS01950 411643..413073 + 1431 WP_043146738.1 N-acetylglucosamine-binding protein GbpA -
BVG91_RS01955 413126..413644 + 519 WP_047568991.1 cytochrome b/b6 domain-containing protein -
BVG91_RS01960 413941..414144 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
BVG91_RS01965 414194..414562 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
BVG91_RS01970 414721..415074 - 354 WP_033647274.1 hypothetical protein -
BVG91_RS01980 415482..416195 + 714 WP_048321317.1 ABC transporter ATP-binding protein -
BVG91_RS01985 416192..417049 + 858 WP_033637343.1 metal ABC transporter permease -
BVG91_RS01990 417075..417953 + 879 WP_041033680.1 metal ABC transporter substrate-binding protein -
BVG91_RS01995 418060..418200 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
BVG91_RS02000 418213..418467 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T70865 WP_004940313.1 NZ_CP018925:c414144-413941 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T70865 NZ_CP018925:c414144-413941 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT70865 WP_004940312.1 NZ_CP018925:c414562-414194 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT70865 NZ_CP018925:c414562-414194 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCACCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References