Detailed information of TA system TA070860

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3421860..3422529
• Replicon: chromosome
• Accession: NZ_CP018923
• Organism: Serratia marcescens strain UMH9

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A2V4FX75
• Locus tag: BVG96_RS16250
• Protein ID: WP_033649453.1
• Coordinates: 3421860..3422282 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8G2G4M4
• Locus tag: BVG96_RS16255
• Protein ID: WP_004931679.1
• Coordinates: 3422263..3422529 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVG96_RS16230	3417749..3418267	+	519	WP_033635825.1	flavodoxin FldB	-
BVG96_RS16235	3418305..3419669	-	1365	WP_060431066.1	cell envelope integrity protein CreD	-
BVG96_RS16240	3419750..3421168	-	1419	WP_033649455.1	two-component system sensor histidine kinase CreC	-
BVG96_RS16245	3421165..3421860	-	696	WP_033649454.1	two-component system response regulator CreB	-
BVG96_RS16250	3421860..3422282	-	423	WP_033649453.1	protein YgfX	Toxin
BVG96_RS16255	3422263..3422529	-	267	WP_004931679.1	FAD assembly factor SdhE	Antitoxin
BVG96_RS16260	3422850..3423842	+	993	WP_033649452.1	tRNA-modifying protein YgfZ	-
BVG96_RS16265	3423881..3424378	-	498	WP_033649451.1	DUF2165 domain-containing protein	-
BVG96_RS16270	3424529..3425203	-	675	WP_033649450.1	hemolysin III family protein	-
BVG96_RS16275	3425387..3425995	+	609	WP_025304127.1	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16471.59 Da
• Isoelectric Point: 10.8114

>T70860 WP_033649453.1 NZ_CP018923:c3422282-3421860 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAAQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLLPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEDP

Nucleotide

• Length: 423 bp

>T70860 NZ_CP018923:c3422282-3421860 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTGTTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGTTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGCGCAGGGCGAGCTGCGGCTGCTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCTGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAGGATCCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10387.89 Da
• Isoelectric Point: 4.7921

>AT70860 WP_004931679.1 NZ_CP018923:c3422529-3422263 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT70860 NZ_CP018923:c3422529-3422263 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGAATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAGTACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: A0A2V4FX75