Detailed information of TA system TA070858

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3070906..3071562
• Replicon: chromosome
• Accession: NZ_CP018923
• Organism: Serratia marcescens strain UMH9

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A2V4G0W2
• Locus tag: BVG96_RS14600
• Protein ID: WP_041036282.1
• Coordinates: 3070906..3071295 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8G2LCA8
• Locus tag: BVG96_RS14605
• Protein ID: WP_004941563.1
• Coordinates: 3071299..3071562 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVG96_RS14585	3067373..3068803	+	1431	WP_060430454.1	multidrug transporter subunit MdtD	-
BVG96_RS14590	3068800..3070182	+	1383	WP_033635541.1	two-component system sensor histidine kinase BaeS	-
BVG96_RS14595	3070182..3070898	+	717	WP_033635542.1	two-component system response regulator BaeR	-
BVG96_RS14600	3070906..3071295	-	390	WP_041036282.1	type II toxin-antitoxin system VapC family toxin	Toxin
BVG96_RS14605	3071299..3071562	-	264	WP_004941563.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
BVG96_RS14610	3071902..3072240	+	339	WP_033635544.1	YegP family protein	-
BVG96_RS14615	3072421..3073773	+	1353	WP_033635545.1	tRNA 5-hydroxyuridine modification protein YegQ	-
BVG96_RS14620	3074240..3075145	+	906	WP_033635546.1	lipid kinase YegS	-
BVG96_RS14625	3075435..3076484	+	1050	WP_033635553.1	class I fructose-bisphosphate aldolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14309.56 Da
• Isoelectric Point: 7.8786

>T70858 WP_041036282.1 NZ_CP018923:c3071295-3070906 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMEKKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Nucleotide

• Length: 390 bp

>T70858 NZ_CP018923:c3071295-3070906 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCCGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGCGCGAACATGGAGAAAAAAGGCAAAATCATGGGCGCGCTGGATCAACTGATCGCCGCGCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10062.31 Da
• Isoelectric Point: 4.6702

>AT70858 WP_004941563.1 NZ_CP018923:c3071562-3071299 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Nucleotide

• Length: 264 bp

>AT70858 NZ_CP018923:c3071562-3071299 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Structures

Toxin

• AlphaFold DB: A0A2V4G0W2