Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1030376..1030901 Replicon chromosome
Accession NZ_CP018923
Organism Serratia marcescens strain UMH9

Toxin (Protein)


Gene name relE Uniprot ID A0A2S4XEJ2
Locus tag BVG96_RS05000 Protein ID WP_033654647.1
Coordinates 1030376..1030660 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B4GIN1
Locus tag BVG96_RS05005 Protein ID WP_004928423.1
Coordinates 1030650..1030901 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG96_RS04975 1025636..1026769 + 1134 WP_060429812.1 putrescine ABC transporter ATP-binding subunit PotG -
BVG96_RS04980 1026794..1027756 + 963 WP_033646669.1 putrescine ABC transporter permease PotH -
BVG96_RS04985 1027753..1028598 + 846 WP_060429814.1 putrescine ABC transporter permease PotI -
BVG96_RS04990 1028703..1029182 + 480 WP_049197168.1 YbjO family protein -
BVG96_RS04995 1029252..1030379 + 1128 WP_060429816.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
BVG96_RS05000 1030376..1030660 - 285 WP_033654647.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BVG96_RS05005 1030650..1030901 - 252 WP_004928423.1 prevent-host-death protein Antitoxin
BVG96_RS05010 1031003..1031737 - 735 WP_043147094.1 arginine ABC transporter substrate-binding protein -
BVG96_RS05015 1031935..1032603 - 669 WP_033637817.1 arginine ABC transporter permease ArtM -
BVG96_RS05020 1032603..1033319 - 717 WP_033637818.1 arginine ABC transporter permease ArtQ -
BVG96_RS05025 1033329..1034060 - 732 WP_033637819.1 arginine ABC transporter substrate-binding protein -
BVG96_RS05030 1034093..1034821 - 729 WP_038884338.1 arginine ABC transporter ATP-binding protein ArtP -
BVG96_RS05035 1035086..1035628 - 543 WP_033637821.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10817.97 Da        Isoelectric Point: 10.6941

>T70848 WP_033654647.1 NZ_CP018923:c1030660-1030376 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLVSVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Download         Length: 285 bp

>T70848 NZ_CP018923:c1030660-1030376 [Serratia marcescens]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGTATCGGTATTGGTTAATCCCCACGTCCCTGCCAACAAACTCGCCGGTTTGCCCGATTGCTACAAAATCA
AACTCAGAGCATCCGGCTTTCGTTTGGTGTATCGCGTCATGGAAACGGAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACGTTCAGCGGCTTACACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9108.39 Da        Isoelectric Point: 4.5203

>AT70848 WP_004928423.1 NZ_CP018923:c1030901-1030650 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Download         Length: 252 bp

>AT70848 NZ_CP018923:c1030901-1030650 [Serratia marcescens]
ATGACGGTTCAACCCATTCTTGCCGATTCCGCAGTCAGCATCAGCGATTTTAAGAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAGCCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCACCGGAAACCTGGGAGGCTA
TCGCGGAGTACCTGGAAGATATCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4XEJ2

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GIN1

References