Detailed information of TA system TA070847

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 892688..893241
• Replicon: chromosome
• Accession: NZ_CP018923
• Organism: Serratia marcescens strain UMH9

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A2V4FZ31
• Locus tag: BVG96_RS04375
• Protein ID: WP_019454426.1
• Coordinates: 892927..893241 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: BVG96_RS04370
• Protein ID: WP_039566839.1
• Coordinates: 892688..892924 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVG96_RS04355	889155..890690	+	1536	WP_033646792.1	glutathione ABC transporter substrate-binding protein GsiB	-
BVG96_RS04360	890743..891663	+	921	WP_033637716.1	glutathione ABC transporter permease GsiC	-
BVG96_RS04365	891673..892581	+	909	WP_019454428.1	glutathione ABC transporter permease GsiD	-
BVG96_RS04370	892688..892924	+	237	WP_039566839.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
BVG96_RS04375	892927..893241	+	315	WP_019454426.1	CcdB family protein	Toxin
BVG96_RS04380	893281..894123	-	843	WP_033654970.1	S-formylglutathione hydrolase	-
BVG96_RS04385	894138..895262	-	1125	WP_033637718.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
BVG96_RS04390	895293..896213	-	921	WP_033654969.1	LysR family transcriptional regulator	-
BVG96_RS04395	896319..897476	+	1158	WP_060387473.1	YbfB/YjiJ family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11745.68 Da
• Isoelectric Point: 5.0488

>T70847 WP_019454426.1 NZ_CP018923:892927-893241 [Serratia marcescens]
MQFTVYANRGNSAVYPLLLDVTSDIIGQLNRRVVIPLLPVEKYPGSTRPERLIPLIRLIDDNEYAVMTYEMASIPVRALG
AEFCDVSQYRTRIKAAIDFLLDGI

Nucleotide

• Length: 315 bp

>T70847 NZ_CP018923:892927-893241 [Serratia marcescens]
ATGCAATTTACGGTGTATGCGAATAGGGGGAACAGCGCGGTTTATCCCCTGCTGCTTGATGTGACGAGCGATATCATTGG
GCAATTAAATCGTCGAGTTGTGATCCCTTTGTTGCCCGTTGAAAAATACCCTGGGAGTACGCGACCGGAACGCTTGATCC
CGTTGATCAGATTGATTGATGACAACGAGTACGCCGTGATGACATATGAAATGGCCAGCATCCCGGTTCGGGCTTTGGGG
GCCGAGTTTTGTGATGTTTCCCAGTATCGGACCAGGATAAAAGCCGCCATCGACTTTCTTCTTGACGGTATTTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9068.10 Da
• Isoelectric Point: 5.7070

>AT70847 WP_039566839.1 NZ_CP018923:892688-892924 [Serratia marcescens]
MPVKQRTTQSVTMTVERSLLSRAREAGINLSATLTAALDAELRQHERIKWQEENREALEALNRFNDEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT70847 NZ_CP018923:892688-892924 [Serratia marcescens]
ATGCCAGTAAAACAACGAACGACGCAAAGTGTGACCATGACGGTGGAACGCAGTTTGTTGAGCCGTGCGCGTGAGGCGGG
GATTAATCTCAGCGCGACGCTAACTGCTGCTTTAGATGCTGAGTTACGTCAGCATGAGAGGATAAAATGGCAGGAAGAAA
ACCGAGAGGCGCTTGAAGCGCTTAACCGATTTAATGATGAGCATGGTTGCTTTAGCGACGAATACAGGACGTTTTAG

Structures

Toxin

• AlphaFold DB: A0A2V4FZ31