Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 424960..425581 Replicon chromosome
Accession NZ_CP018923
Organism Serratia marcescens strain UMH9

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag BVG96_RS02025 Protein ID WP_004940313.1
Coordinates 424960..425163 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag BVG96_RS02030 Protein ID WP_004940312.1
Coordinates 425213..425581 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG96_RS02000 420751..421197 + 447 WP_033647279.1 type II secretion system protein M -
BVG96_RS02005 421234..422049 + 816 WP_060426613.1 A24 family peptidase -
BVG96_RS02010 422046..422408 - 363 WP_060429632.1 type II secretion system pilot lipoprotein GspS -
BVG96_RS02015 422662..424092 + 1431 WP_033637339.1 N-acetylglucosamine-binding protein GbpA -
BVG96_RS02020 424145..424663 + 519 WP_033647275.1 cytochrome b/b6 domain-containing protein -
BVG96_RS02025 424960..425163 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
BVG96_RS02030 425213..425581 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
BVG96_RS02035 425740..426093 - 354 WP_060422005.1 hypothetical protein -
BVG96_RS02045 426500..427213 + 714 WP_033647273.1 ABC transporter ATP-binding protein -
BVG96_RS02050 427210..428067 + 858 WP_060426364.1 metal ABC transporter permease -
BVG96_RS02055 428093..428971 + 879 WP_060429634.1 metal ABC transporter substrate-binding protein -
BVG96_RS02060 429078..429218 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
BVG96_RS02065 429231..429485 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T70846 WP_004940313.1 NZ_CP018923:c425163-424960 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T70846 NZ_CP018923:c425163-424960 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT70846 WP_004940312.1 NZ_CP018923:c425581-425213 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT70846 NZ_CP018923:c425581-425213 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCACCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References