Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 3789956..3790428 Replicon chromosome
Accession NZ_CP018917
Organism Serratia marcescens strain UMH5

Toxin (Protein)


Gene name relE Uniprot ID A0A5C7D428
Locus tag BVG97_RS18305 Protein ID WP_049208401.1
Coordinates 3789956..3790231 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5C7D116
Locus tag BVG97_RS18310 Protein ID WP_049200097.1
Coordinates 3790237..3790428 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG97_RS18280 3785276..3786556 - 1281 WP_089186451.1 polysaccharide deacetylase family protein -
BVG97_RS18285 3786734..3787504 - 771 WP_004937535.1 ABC transporter permease -
BVG97_RS18290 3787501..3788424 - 924 WP_033644695.1 ABC transporter ATP-binding protein -
BVG97_RS18295 3788635..3789291 + 657 WP_049200096.1 carbonate dehydratase -
BVG97_RS18300 3789329..3789865 - 537 WP_048234659.1 hypoxanthine phosphoribosyltransferase -
BVG97_RS18305 3789956..3790231 - 276 WP_049208401.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BVG97_RS18310 3790237..3790428 - 192 WP_049200097.1 hypothetical protein Antitoxin
BVG97_RS18315 3790534..3792243 - 1710 WP_089186452.1 multicopper oxidase CueO -
BVG97_RS18320 3792462..3792809 + 348 WP_004937515.1 YacC family pilotin-like protein -
BVG97_RS18325 3792934..3793797 + 864 WP_089186453.1 polyamine aminopropyltransferase -
BVG97_RS18330 3793825..3794619 + 795 WP_049200100.1 adenosylmethionine decarboxylase -
BVG97_RS18335 3794652..3795014 - 363 WP_004937507.1 protein YacL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10410.13 Da        Isoelectric Point: 6.8785

>T70842 WP_049208401.1 NZ_CP018917:c3790231-3789956 [Serratia marcescens]
MLTVKWTDEAKTGLYTLLAFIAERNPLAAEALLQRIEESVIPLAEHPYLFRPGRVNGTREMVVHPNYIVVYRVLAAHIEI
VSVLHARQEYP

Download         Length: 276 bp

>T70842 NZ_CP018917:c3790231-3789956 [Serratia marcescens]
ATGTTAACCGTCAAATGGACTGACGAAGCAAAAACGGGTTTATATACGCTGCTGGCTTTTATCGCTGAGCGAAATCCACT
TGCCGCAGAGGCTTTGTTGCAACGCATTGAAGAGTCGGTTATCCCGTTAGCGGAACATCCTTATCTATTCAGGCCAGGCA
GGGTGAACGGGACTCGTGAAATGGTTGTTCATCCTAATTACATTGTGGTTTACCGCGTGCTGGCTGCACATATTGAAATA
GTGAGTGTCCTGCACGCTCGTCAGGAATACCCTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7188.98 Da        Isoelectric Point: 5.6492

>AT70842 WP_049200097.1 NZ_CP018917:c3790428-3790237 [Serratia marcescens]
MPTKLDPIVSEFETQEQADSYDRWFRSTVESSINSDSPRIPHDEVMAGARHIIEQAKAKRKSA

Download         Length: 192 bp

>AT70842 NZ_CP018917:c3790428-3790237 [Serratia marcescens]
ATGCCGACAAAATTGGATCCCATCGTTTCTGAGTTTGAGACTCAAGAGCAGGCTGATAGCTACGATCGTTGGTTCAGAAG
CACCGTGGAATCTTCCATCAATAGCGACTCCCCCCGTATTCCCCATGACGAAGTCATGGCCGGCGCTCGTCACATTATCG
AGCAGGCAAAAGCCAAAAGAAAATCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D428

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7D116

References