Detailed information of TA system TA070841

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3666681..3667350
• Replicon: chromosome
• Accession: NZ_CP018917
• Organism: Serratia marcescens strain UMH5

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: BVG97_RS17715
• Protein ID: WP_089186426.1
• Coordinates: 3666681..3667103 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: BVG97_RS17720
• Protein ID: WP_019455657.1
• Coordinates: 3667084..3667350 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVG97_RS17695	3662571..3663089	+	519	WP_038871234.1	flavodoxin FldB	-
BVG97_RS17700	3663126..3664490	-	1365	WP_049277063.1	cell envelope integrity protein CreD	-
BVG97_RS17705	3664571..3665989	-	1419	WP_089186425.1	two-component system sensor histidine kinase CreC	-
BVG97_RS17710	3665986..3666681	-	696	WP_033644777.1	two-component system response regulator CreB	-
BVG97_RS17715	3666681..3667103	-	423	WP_089186426.1	protein YgfX	Toxin
BVG97_RS17720	3667084..3667350	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
BVG97_RS17725	3667671..3668663	+	993	WP_049199219.1	tRNA-modifying protein YgfZ	-
BVG97_RS17730	3668702..3669199	-	498	WP_060422863.1	DUF2165 domain-containing protein	-
BVG97_RS17735	3669350..3670024	-	675	WP_038871224.1	hemolysin III family protein	-
BVG97_RS17740	3670208..3670816	+	609	WP_060422860.1	HD domain-containing protein	-
BVG97_RS17745	3670849..3671775	-	927	WP_038871218.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16468.52 Da
• Isoelectric Point: 10.8114

>T70841 WP_089186426.1 NZ_CP018917:c3667103-3666681 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGLGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDSEEA

Nucleotide

• Length: 423 bp

>T70841 NZ_CP018917:c3667103-3666681 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACTCAGCTGTTTTCCCTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTGGGCCCGCTCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGCGAGCTGCGGCTGCTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCAGCCGACGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGTCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACAGCGAGGAGGCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT70841 WP_019455657.1 NZ_CP018917:c3667350-3667084 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT70841 NZ_CP018917:c3667350-3667084 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGTTGTTCATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04