Detailed information of TA system TA070840

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH
• Location: 3658308..3659031
• Replicon: chromosome
• Accession: NZ_CP018917
• Organism: Serratia marcescens strain UMH5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1L6QMX6
• Locus tag: BVG97_RS17670
• Protein ID: WP_060422886.1
• Coordinates: 3658308..3658694 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BVG97_RS17675
• Protein ID: WP_084827195.1
• Coordinates: 3658687..3659031 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVG97_RS17660	3655421..3656938	-	1518	WP_033649459.1	lysine--tRNA ligase	-
BVG97_RS17670	3658308..3658694	+	387	WP_060422886.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BVG97_RS17675	3658687..3659031	+	345	WP_084827195.1	helix-turn-helix domain-containing protein	Antitoxin
BVG97_RS17680	3659082..3660815	-	1734	WP_084827194.1	single-stranded-DNA-specific exonuclease RecJ	-
BVG97_RS17685	3660822..3661538	-	717	WP_060441317.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
BVG97_RS17690	3661565..3662464	-	900	WP_060441367.1	site-specific tyrosine recombinase XerD	-
BVG97_RS17695	3662571..3663089	+	519	WP_038871234.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (54-91)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14524.52 Da
• Isoelectric Point: 9.0130

>T70840 WP_060422886.1 NZ_CP018917:3658308-3658694 [Serratia marcescens]
MDIFVTDDFDKFMKKNRIVDQKICTAAHELAHGNHDGDLGGGVYKKRISLNRGKRGGARSIVAFKRGHHQYFVDGWLKNA
VKQSGAKEINDDELATYRELARDFLAMPPEIIKRAIDSGYLREVKCDD

Nucleotide

• Length: 387 bp

>T70840 NZ_CP018917:3658308-3658694 [Serratia marcescens]
ATGGACATTTTCGTCACGGATGATTTCGACAAATTTATGAAGAAAAATCGCATCGTCGATCAAAAGATTTGCACGGCGGC
TCACGAACTCGCGCACGGTAACCATGACGGCGATCTGGGCGGCGGCGTCTACAAGAAGCGCATTTCGCTCAATCGGGGTA
AACGAGGTGGAGCCCGATCCATCGTGGCGTTTAAACGCGGACATCATCAGTATTTTGTTGATGGGTGGCTGAAAAACGCC
GTAAAACAGAGCGGTGCAAAAGAAATCAACGATGATGAATTGGCAACCTATCGCGAGCTCGCCAGAGATTTTCTTGCCAT
GCCGCCGGAAATTATCAAACGAGCCATCGATAGCGGCTACTTGCGAGAGGTGAAATGCGATGACTGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12947.91 Da
• Isoelectric Point: 11.6257

>AT70840 WP_084827195.1 NZ_CP018917:3658687-3659031 [Serratia marcescens]
MTDNRLLRLQKMAQRFNEVGAVSDDTVRNITARVQAQEQHARREQHEQMDGARIKMLRRRLGLSQADLAAVVNMSTTSVQ
KWERNAVKPQGAALRMLEIIEQKGVASLIISPRN

Nucleotide

• Length: 345 bp

>AT70840 NZ_CP018917:3658687-3659031 [Serratia marcescens]
ATGACTGATAATCGCCTGCTCAGACTGCAAAAAATGGCACAGCGTTTTAATGAGGTCGGTGCCGTGTCAGACGACACCGT
GCGCAACATCACTGCGCGAGTTCAGGCGCAGGAACAACATGCCCGGCGTGAACAGCATGAGCAAATGGACGGCGCACGCA
TCAAAATGCTGCGCAGACGGCTCGGCCTGAGCCAGGCCGATCTGGCGGCCGTGGTCAACATGTCGACCACCAGCGTACAA
AAATGGGAACGTAACGCGGTAAAACCCCAGGGAGCCGCGCTCAGAATGCTGGAGATTATCGAACAGAAAGGGGTCGCCAG
CCTGATCATCTCGCCACGAAACTGA

Structures

Toxin

• AlphaFold DB: A0A1L6QMX6