Detailed information of TA system TA070839

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 3428486..3429219
• Replicon: chromosome
• Accession: NZ_CP018917
• Organism: Serratia marcescens strain UMH5

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: BVG97_RS16610
• Protein ID: WP_089186385.1
• Coordinates: 3428890..3429219 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: BVG97_RS16605
• Protein ID: WP_089186384.1
• Coordinates: 3428486..3428851 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVG97_RS16560	3423796..3424500	+	705	WP_089186375.1	WYL domain-containing protein	-
BVG97_RS16565	3424500..3425069	+	570	WP_089186376.1	hypothetical protein	-
BVG97_RS16570	3425106..3425558	+	453	WP_089186377.1	hypothetical protein	-
BVG97_RS16575	3425555..3426004	+	450	WP_089186378.1	hypothetical protein	-
BVG97_RS16580	3426063..3426293	+	231	WP_089186379.1	DUF905 family protein	-
BVG97_RS16585	3426392..3427213	+	822	WP_089186380.1	DUF945 domain-containing protein	-
BVG97_RS16590	3427244..3427687	+	444	WP_089186381.1	antirestriction protein	-
BVG97_RS16595	3427700..3428242	+	543	WP_089186382.1	DNA repair protein RadC	-
BVG97_RS16600	3428239..3428460	+	222	WP_089186383.1	DUF987 family protein	-
BVG97_RS16605	3428486..3428851	+	366	WP_089186384.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
BVG97_RS16610	3428890..3429219	+	330	WP_089186385.1	TA system toxin CbtA family protein	Toxin
BVG97_RS16615	3430195..3430914	-	720	WP_060441107.1	response regulator transcription factor	-
BVG97_RS16620	3431041..3432012	-	972	WP_072271068.1	fimbrial protein	-
BVG97_RS16625	3432029..3432532	-	504	WP_089186386.1	type 1 fimbrial protein	-
BVG97_RS16630	3432545..3433069	-	525	WP_089186387.1	type 1 fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fimG / fimD / fimC	3341409..3474089	132680

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (17-117)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12433.24 Da
• Isoelectric Point: 8.9981

>T70839 WP_089186385.1 NZ_CP018917:3428890-3429219 [Serratia marcescens]
MQTLSSHPTRATQPCLSPVEIWQRLLTHLLLQHYGLTLNDTPFSNETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILRARRSTGLLKTNVK

Nucleotide

• Length: 330 bp

>T70839 NZ_CP018917:3428890-3429219 [Serratia marcescens]
ATGCAAACCTTATCATCACACCCGACACGGGCGACTCAGCCCTGCCTGTCGCCCGTTGAAATCTGGCAACGGCTGCTGAC
TCATCTGTTATTGCAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTAATGAAACCACCATACGGGAACATATTG
ATGCAGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATACGGGCTTGTCCGTATCGACCGGAAGGGATTT
TCGTGGCAAGAACAAACCCCGTATATTTCCGTAGTGGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
CGTGAAATAA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13459.16 Da
• Isoelectric Point: 6.6212

>AT70839 WP_089186384.1 NZ_CP018917:3428486-3428851 [Serratia marcescens]
MNNHSVSGTTPEDTSSQQWGLKRCITPCFGARLVQEGNRLHFIADRAGFSGAFSDNDGLRLDQAFPLMLKKLELMLISGE
LNPRHQHCVTLHNNGLTCEAYTRGSCGYVYIAVYPDQTEPQ

Nucleotide

• Length: 366 bp

>AT70839 NZ_CP018917:3428486-3428851 [Serratia marcescens]
ATGAACAATCACTCTGTATCCGGCACCACGCCGGAGGATACCTCCTCTCAGCAGTGGGGGTTAAAACGCTGTATTACACC
CTGTTTTGGAGCCCGCCTGGTACAGGAAGGCAACCGACTGCATTTTATTGCTGATCGAGCCGGATTTAGCGGTGCTTTCA
GTGACAACGACGGGTTGCGACTCGACCAGGCTTTTCCATTGATGCTAAAGAAGTTGGAGCTGATGCTGATTAGTGGCGAA
CTCAATCCCCGTCACCAGCACTGCGTCACACTACACAACAACGGGCTCACTTGCGAAGCCTACACACGCGGCTCTTGCGG
CTATGTCTACATTGCCGTTTATCCCGATCAGACTGAGCCACAGTAA