Detailed information of TA system TA070836

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2482048..2482679
• Replicon: chromosome
• Accession: NZ_CP018917
• Organism: Serratia marcescens strain UMH5

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A5C7D7C3
• Locus tag: BVG97_RS12070
• Protein ID: WP_033640020.1
• Coordinates: 2482048..2482446 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BVG97_RS12075
• Protein ID: WP_084827643.1
• Coordinates: 2482446..2482679 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVG97_RS12045	2477623..2477997	+	375	WP_084827647.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BVG97_RS12050	2477990..2478292	+	303	WP_084827646.1	DNA-binding transcriptional regulator	-
BVG97_RS12055	2478295..2478699	-	405	WP_060420791.1	flagellar protein FlhE	-
BVG97_RS12060	2478699..2480777	-	2079	WP_089186103.1	flagellar biosynthesis protein FlhA	-
BVG97_RS12065	2480770..2481921	-	1152	WP_047730459.1	flagellar type III secretion system protein FlhB	-
BVG97_RS12070	2482048..2482446	-	399	WP_033640020.1	type II toxin-antitoxin system VapC family toxin	Toxin
BVG97_RS12075	2482446..2482679	-	234	WP_084827643.1	antitoxin	Antitoxin
BVG97_RS12080	2482805..2483449	-	645	WP_004934858.1	protein phosphatase CheZ	-
BVG97_RS12085	2483460..2483849	-	390	WP_060420785.1	chemotaxis response regulator CheY	-
BVG97_RS12090	2483952..2485001	-	1050	WP_015378262.1	chemotaxis response regulator protein-glutamate methylesterase	-
BVG97_RS12095	2485001..2485872	-	872	Protein_2371	protein-glutamate O-methyltransferase CheR	-
BVG97_RS12100	2485910..2487526	-	1617	WP_047730456.1	Tar ligand binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

• SpoVT-AbrB domain (7-45)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14918.11 Da
• Isoelectric Point: 8.4955

>T70836 WP_033640020.1 NZ_CP018917:c2482446-2482048 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Nucleotide

• Length: 399 bp

>T70836 NZ_CP018917:c2482446-2482048 [Serratia marcescens]
ATGTTCAGCCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGCCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATCACCTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGCCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCAGCATCGCACTAC
GGCAACATCCGCGCTGCGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGCCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8855.82 Da
• Isoelectric Point: 4.7815

>AT70836 WP_084827643.1 NZ_CP018917:c2482679-2482446 [Serratia marcescens]
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFSAENEVSDDFLNERAGQHQREREDF

Nucleotide

• Length: 234 bp

>AT70836 NZ_CP018917:c2482679-2482446 [Serratia marcescens]
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCTTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGATAGCTTCTTCTCTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGGCAGCACCAGCGCGAGCGGGAAGATTTTTGA

Structures

Toxin

• AlphaFold DB: A0A5C7D7C3