Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 452921..453543 Replicon chromosome
Accession NZ_CP018917
Organism Serratia marcescens strain UMH5

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag BVG97_RS02190 Protein ID WP_004940313.1
Coordinates 452921..453124 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag BVG97_RS02195 Protein ID WP_004940312.1
Coordinates 453175..453543 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG97_RS02165 448731..449177 + 447 WP_089185567.1 type II secretion system protein M -
BVG97_RS02170 449213..450028 + 816 WP_089185568.1 A24 family peptidase -
BVG97_RS02175 450025..450387 - 363 WP_060423419.1 type II secretion system pilot lipoprotein GspS -
BVG97_RS02180 450640..452067 + 1428 WP_060440565.1 N-acetylglucosamine-binding protein GbpA -
BVG97_RS02185 452120..452638 + 519 WP_060423424.1 cytochrome b/b6 domain-containing protein -
BVG97_RS02190 452921..453124 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
BVG97_RS02195 453175..453543 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
BVG97_RS02200 453702..454055 - 354 WP_060423427.1 hypothetical protein -
BVG97_RS26580 454328..454468 + 141 WP_154292170.1 hypothetical protein -
BVG97_RS02205 454465..455178 + 714 WP_089185569.1 ABC transporter ATP-binding protein -
BVG97_RS02210 455175..456032 + 858 WP_060440564.1 metal ABC transporter permease -
BVG97_RS02215 456058..456936 + 879 WP_089185570.1 metal ABC transporter substrate-binding protein -
BVG97_RS02220 457043..457183 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
BVG97_RS02225 457196..457450 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T70827 WP_004940313.1 NZ_CP018917:c453124-452921 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T70827 NZ_CP018917:c453124-452921 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT70827 WP_004940312.1 NZ_CP018917:c453543-453175 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT70827 NZ_CP018917:c453543-453175 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGCATCGC
GACCCTGGGAGACAGCCACCACGGGTGGGTCAACGATCCGACATCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACTTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAGACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References