Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3476355..3477024 Replicon chromosome
Accession NZ_CP018915
Organism Serratia marcescens strain UMH1

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag BVG95_RS16490 Protein ID WP_025304123.1
Coordinates 3476355..3476777 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag BVG95_RS16495 Protein ID WP_004931679.1
Coordinates 3476758..3477024 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG95_RS16470 3472244..3472762 + 519 WP_033635825.1 flavodoxin FldB -
BVG95_RS16475 3472800..3474164 - 1365 WP_089196232.1 cell envelope integrity protein CreD -
BVG95_RS16480 3474245..3475663 - 1419 WP_089196233.1 two-component system sensor histidine kinase CreC -
BVG95_RS16485 3475660..3476355 - 696 WP_025304122.1 two-component system response regulator CreB -
BVG95_RS16490 3476355..3476777 - 423 WP_025304123.1 protein YgfX Toxin
BVG95_RS16495 3476758..3477024 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
BVG95_RS16500 3477345..3478337 + 993 WP_049208207.1 tRNA-modifying protein YgfZ -
BVG95_RS16505 3478376..3478873 - 498 WP_025304125.1 DUF2165 domain-containing protein -
BVG95_RS16510 3479024..3479698 - 675 WP_033639467.1 hemolysin III family protein -
BVG95_RS16515 3479882..3480490 + 609 WP_049208209.1 HD domain-containing protein -
BVG95_RS16520 3480531..3481457 - 927 WP_060434995.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16525.62 Da        Isoelectric Point: 10.8432

>T70824 WP_025304123.1 NZ_CP018915:c3476777-3476355 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGYGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGLLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGNGEEP

Download         Length: 423 bp

>T70824 NZ_CP018915:c3476777-3476355 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTTTTTTCCCTGTTGACTCATGGCGTTCTGATCTT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGTTATGGCCCGCTTTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGTAGCCAGAAGCGCATCGCCGCAGTGCAGGGCGAGCTGCGGCTGCTGGCGGACCGGCGTTTCAGCTGGCACGGCCGA
GAATGGCGGCTGGCGAAAAAGCCCTGGATGCCGGGCTACGGCCTGCTGCTGACGCTGCAGCCGATGGAAGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTAACGGCGAGGAACCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT70824 WP_004931679.1 NZ_CP018915:c3477024-3476758 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT70824 NZ_CP018915:c3477024-3476758 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References