Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH
Location 3467981..3468704 Replicon chromosome
Accession NZ_CP018915
Organism Serratia marcescens strain UMH1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BVG95_RS16445 Protein ID WP_049296187.1
Coordinates 3467981..3468367 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag BVG95_RS16450 Protein ID WP_025304117.1
Coordinates 3468360..3468704 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG95_RS16425 3463360..3464670 + 1311 WP_089196230.1 MFS transporter -
BVG95_RS16435 3465094..3466611 - 1518 WP_004931697.1 lysine--tRNA ligase -
BVG95_RS16445 3467981..3468367 + 387 WP_049296187.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BVG95_RS16450 3468360..3468704 + 345 WP_025304117.1 helix-turn-helix domain-containing protein Antitoxin
BVG95_RS16455 3468755..3470488 - 1734 WP_089196231.1 single-stranded-DNA-specific exonuclease RecJ -
BVG95_RS16460 3470495..3471211 - 717 WP_025304118.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BVG95_RS16465 3471238..3472158 - 921 WP_154747450.1 site-specific tyrosine recombinase XerD -
BVG95_RS16470 3472244..3472762 + 519 WP_033635825.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(54-91)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14614.65 Da        Isoelectric Point: 9.4235

>T70823 WP_049296187.1 NZ_CP018915:3467981-3468367 [Serratia marcescens]
MDIFVTDDFDKFMKKNRIVDQKICTAAHELAHGNHDGDLGGGVYKKRISLNRGKRGGARSIVAFKRGRHQYFIDGWLKNT
VKQNGAKEINDDELATYRELARDFLAMPPEIIKRAIDSGYLREVKCDD

Download         Length: 387 bp

>T70823 NZ_CP018915:3467981-3468367 [Serratia marcescens]
ATGGACATTTTCGTCACGGATGATTTCGACAAATTTATGAAGAAAAATCGCATCGTCGATCAAAAGATTTGCACCGCGGC
TCACGAACTCGCACACGGTAACCATGACGGCGATCTGGGCGGCGGCGTCTACAAGAAACGTATTTCGCTCAATCGGGGTA
AACGGGGTGGCGCTCGATCCATCGTGGCGTTTAAACGCGGTCGTCATCAGTATTTTATTGATGGATGGCTGAAAAACACC
GTAAAACAGAACGGTGCAAAAGAAATCAACGATGATGAATTGGCAACCTATCGCGAGCTCGCCAGAGATTTTCTTGCCAT
GCCGCCGGAAATTATCAAACGAGCCATCGATAGCGGCTACTTGCGAGAGGTGAAATGCGATGACTGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12919.85 Da        Isoelectric Point: 11.4121

>AT70823 WP_025304117.1 NZ_CP018915:3468360-3468704 [Serratia marcescens]
MTDNRLLRLQKMAQRFNEIGAVSDDTVRNIATRVQAQEQHAQREQHDQMDGARIKMLRRRLGLSQADLAAVVNMSTTSVQ
KWERNAVKPQGAALRMLEIIEQKGVASLIISPRN

Download         Length: 345 bp

>AT70823 NZ_CP018915:3468360-3468704 [Serratia marcescens]
ATGACTGATAATCGCCTGCTCAGACTGCAAAAAATGGCACAGCGTTTTAATGAGATCGGTGCGGTGTCAGACGATACCGT
ACGCAACATCGCCACACGAGTACAGGCGCAGGAACAACATGCCCAGCGTGAGCAGCATGATCAAATGGACGGCGCACGCA
TCAAAATGCTGCGCAGACGGCTTGGCTTGAGCCAGGCCGATTTAGCGGCCGTGGTCAACATGTCGACCACCAGCGTACAA
AAATGGGAACGTAACGCGGTAAAACCCCAGGGAGCCGCGCTCAGAATGCTGGAAATTATCGAACAGAAAGGGGTCGCCAG
CCTGATCATCTCACCACGAAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References