Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3122126..3122782 Replicon chromosome
Accession NZ_CP018915
Organism Serratia marcescens strain UMH1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BVG95_RS14830 Protein ID WP_049204858.1
Coordinates 3122126..3122515 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag BVG95_RS14835 Protein ID WP_004941563.1
Coordinates 3122519..3122782 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG95_RS14815 3118593..3120023 + 1431 WP_049296101.1 MFS transporter -
BVG95_RS14820 3120020..3121402 + 1383 WP_049204856.1 two-component system sensor histidine kinase BaeS -
BVG95_RS14825 3121402..3122118 + 717 WP_004941568.1 two-component system response regulator BaeR -
BVG95_RS14830 3122126..3122515 - 390 WP_049204858.1 type II toxin-antitoxin system VapC family toxin Toxin
BVG95_RS14835 3122519..3122782 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BVG95_RS14840 3123120..3123458 + 339 WP_016926703.1 YegP family protein -
BVG95_RS14845 3123637..3124989 + 1353 WP_025303865.1 tRNA 5-hydroxyuridine modification protein YegQ -
BVG95_RS24395 3125206..3125427 - 222 WP_141998673.1 hypothetical protein -
BVG95_RS14850 3125457..3126362 + 906 WP_043137977.1 lipid kinase YegS -
BVG95_RS14855 3126531..3127745 + 1215 WP_025303867.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14423.73 Da        Isoelectric Point: 9.0823

>T70821 WP_049204858.1 NZ_CP018915:c3122515-3122126 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMQKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDREAARCYGEM
RANMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T70821 NZ_CP018915:c3122515-3122126 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGCAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCCAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCGGTGACGGTCTATGCATGGGATCGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGGGCAAACATGGAGAGAAAGGGCAAAATCATGGGCGCGATGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT70821 WP_004941563.1 NZ_CP018915:c3122782-3122519 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT70821 NZ_CP018915:c3122782-3122519 [Serratia marcescens]
ATGGAAAGAATCGCCAAGCTGTTTAAAAACGGTAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTGTATATCCGTCGCGATCGGGAGGGAAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References