Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3023282..3023844 Replicon chromosome
Accession NZ_CP018915
Organism Serratia marcescens strain UMH1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag BVG95_RS14385 Protein ID WP_025303801.1
Coordinates 3023282..3023638 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag BVG95_RS14390 Protein ID WP_004936539.1
Coordinates 3023635..3023844 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG95_RS14365 3019018..3019815 - 798 WP_025303797.1 energy transducer TonB -
BVG95_RS14370 3019918..3020757 - 840 WP_025303798.1 ChaN family lipoprotein -
BVG95_RS14375 3020935..3022344 + 1410 WP_089196143.1 S-methylmethionine permease -
BVG95_RS14380 3022334..3023272 + 939 WP_089196144.1 homocysteine S-methyltransferase -
BVG95_RS14385 3023282..3023638 - 357 WP_025303801.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
BVG95_RS14390 3023635..3023844 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BVG95_RS14395 3023954..3026233 - 2280 WP_016926766.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
BVG95_RS24580 3026449..3026622 - 174 WP_201260710.1 hypothetical protein -
BVG95_RS14400 3026603..3026983 - 381 WP_043140376.1 DUF2570 family protein -
BVG95_RS14405 3026980..3027381 - 402 WP_025303803.1 M15 family metallopeptidase -
BVG95_RS14410 3027371..3027697 - 327 WP_033643982.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13163.93 Da        Isoelectric Point: 4.9139

>T70820 WP_025303801.1 NZ_CP018915:c3023638-3023282 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLTE

Download         Length: 357 bp

>T70820 NZ_CP018915:c3023638-3023282 [Serratia marcescens]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAGTTCAATGCTGAAATTGTGCCTCACGGCCGCCAGGAAGGCAGCAAAGT
TGAGGCTGTAGCCAACCGCGTGCTCAATGCTTACCACTACGAGAACGTCACAGACGTTTACCGCTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGACGCAGAACTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTTGA
ACAAGCCGCTGAACACTTACGCCGGCTAACCGAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT70820 WP_004936539.1 NZ_CP018915:c3023844-3023635 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT70820 NZ_CP018915:c3023844-3023635 [Serratia marcescens]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTTTTGGTCAAAGCCAAAGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References