Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 874867..875414 Replicon chromosome
Accession NZ_CP018915
Organism Serratia marcescens strain UMH1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag BVG95_RS04310 Protein ID WP_049208872.1
Coordinates 875106..875414 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag BVG95_RS04305 Protein ID WP_025302143.1
Coordinates 874867..875103 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG95_RS04290 871353..872888 + 1536 WP_025302140.1 glutathione ABC transporter substrate-binding protein GsiB -
BVG95_RS04295 872941..873861 + 921 WP_025302141.1 glutathione ABC transporter permease GsiC -
BVG95_RS04300 873871..874779 + 909 WP_169540348.1 glutathione ABC transporter permease GsiD -
BVG95_RS04305 874867..875103 + 237 WP_025302143.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
BVG95_RS04310 875106..875414 + 309 WP_049208872.1 CcdB family protein Toxin
BVG95_RS04315 875454..876296 - 843 WP_015377214.1 S-formylglutathione hydrolase -
BVG95_RS04320 876311..877435 - 1125 WP_016928454.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
BVG95_RS04325 877466..878386 - 921 WP_043142419.1 LysR family transcriptional regulator -
BVG95_RS04330 878492..879649 + 1158 WP_043142422.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - galU / wza / manB / wcaJ / galE / gnd 702227..976241 274014


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11518.35 Da        Isoelectric Point: 5.0196

>T70810 WP_049208872.1 NZ_CP018915:875106-875414 [Serratia marcescens]
MQFTVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAIRISQIGKA
VGNVNEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

>T70810 NZ_CP018915:875106-875414 [Serratia marcescens]
ATGCAATTTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGTCCTCTCGACCCGGTTAATGATCCCCCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGG
AGATTGAGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCATACGTATTTCGCAGATTGGGAAGGCC
GTTGGTAATGTCAATGAGCACAGGAATCAAATTAAAGCCGCTATCGATTTTCTGATTGATGGCTTTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8967.04 Da        Isoelectric Point: 5.0807

>AT70810 WP_025302143.1 NZ_CP018915:874867-875103 [Serratia marcescens]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT70810 NZ_CP018915:874867-875103 [Serratia marcescens]
ATGGCAAATAGCAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCCGTATTGACGGACGCATTGAGCGTCCGCGTCAGGGATATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGCGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References