Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 392072..392694 Replicon chromosome
Accession NZ_CP018915
Organism Serratia marcescens strain UMH1

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag BVG95_RS01850 Protein ID WP_004940313.1
Coordinates 392072..392275 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag BVG95_RS01855 Protein ID WP_004940312.1
Coordinates 392326..392694 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG95_RS01820 387771..388109 + 339 WP_004940327.1 P-II family nitrogen regulator -
BVG95_RS01825 388146..389432 + 1287 WP_038628958.1 ammonium transporter AmtB -
BVG95_RS01830 389523..390386 - 864 WP_016928847.1 acyl-CoA thioesterase II -
BVG95_RS01835 390618..391109 + 492 WP_025301777.1 YbaY family lipoprotein -
BVG95_RS01840 391174..391488 - 315 WP_025301778.1 MGMT family protein -
BVG95_RS01850 392072..392275 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
BVG95_RS01855 392326..392694 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
BVG95_RS01860 392853..393206 - 354 WP_025301779.1 hypothetical protein -
BVG95_RS01870 393615..394328 + 714 WP_025301780.1 ABC transporter ATP-binding protein -
BVG95_RS01875 394325..395182 + 858 WP_025301781.1 metal ABC transporter permease -
BVG95_RS01880 395208..396086 + 879 WP_049209312.1 metal ABC transporter substrate-binding protein -
BVG95_RS01885 396194..396334 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
BVG95_RS01890 396347..396601 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T70809 WP_004940313.1 NZ_CP018915:c392275-392072 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T70809 NZ_CP018915:c392275-392072 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT70809 WP_004940312.1 NZ_CP018915:c392694-392326 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT70809 NZ_CP018915:c392694-392326 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGCTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GATGATACCTATACGCTGTTCAGCAGTTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References