Detailed information of TA system TA070805

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-higA/BrnT_toxin-HTH
• Location: 2070654..2071191
• Replicon: chromosome
• Accession: NZ_CP018911
• Organism: Glycocaulis alkaliphilus strain 6B-8

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: -
• Locus tag: X907_RS09840
• Protein ID: WP_127567523.1
• Coordinates: 2070898..2071191 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: X907_RS09835
• Protein ID: WP_127567521.1
• Coordinates: 2070654..2070917 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
X907_RS09820	2066519..2067391	+	873	WP_127567515.1	NAD(P)-dependent oxidoreductase	-
X907_RS09825	2067566..2069260	-	1695	WP_127567517.1	HAMP domain-containing protein	-
X907_RS09830	2069424..2070650	-	1227	WP_127567519.1	TIGR03862 family flavoprotein	-
X907_RS09835	2070654..2070917	-	264	WP_127567521.1	helix-turn-helix domain-containing protein	Antitoxin
X907_RS09840	2070898..2071191	-	294	WP_127567523.1	BrnT family toxin	Toxin
X907_RS09845	2071210..2072022	-	813	WP_127567525.1	sulfite exporter TauE/SafE family protein	-
X907_RS09850	2072022..2073014	-	993	WP_127569453.1	tRNA dihydrouridine(20/20a) synthase DusA	-
X907_RS09855	2073258..2074118	+	861	WP_127567527.1	hypothetical protein	-
X907_RS09860	2074236..2075357	+	1122	WP_127567529.1	carbon-nitrogen hydrolase family protein	-
X907_RS09865	2075425..2075820	+	396	WP_127567532.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (10-87)

Antitoxin

• Cro/C1-type helix-turn-helix domain (27-65)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11157.53 Da
• Isoelectric Point: 6.2302

>T70805 WP_127567523.1 NZ_CP018911:c2071191-2070898 [Glycocaulis alkaliphilus]
MPYTWSKLDYDPEKDEANFAKHGVPLGFAAMVLADRGKVDVLDTRFDYGEERFVTYGLAEGRVWVCVHAPRDGVARIISV
RKANERETERYHGEQRP

Nucleotide

• Length: 294 bp

>T70805 NZ_CP018911:c2071191-2070898 [Glycocaulis alkaliphilus]
TTGCCGTATACTTGGTCAAAGCTGGACTACGATCCTGAGAAGGATGAAGCCAACTTCGCCAAGCATGGCGTCCCGCTAGG
CTTTGCCGCAATGGTGCTGGCGGACCGGGGCAAGGTCGATGTGCTGGATACCCGGTTCGACTATGGCGAGGAGCGCTTTG
TCACCTACGGGCTCGCAGAAGGACGGGTCTGGGTATGCGTCCATGCACCAAGGGATGGCGTGGCCCGCATCATTTCGGTG
AGGAAAGCCAATGAGCGTGAGACAGAAAGATATCATGGCGAGCAACGCCCCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9267.39 Da
• Isoelectric Point: 9.8869

>AT70805 WP_127567521.1 NZ_CP018911:c2070917-2070654 [Glycocaulis alkaliphilus]
MASNAPDPDAPLSDEEFERGRAAVLARKARSATGLSQPAFAARYGVPVASLRDWEQGRRKPDAATRNYLRVIASMPDAVA
RALDGAA

Nucleotide

• Length: 264 bp

>AT70805 NZ_CP018911:c2070917-2070654 [Glycocaulis alkaliphilus]
ATGGCGAGCAACGCCCCTGATCCCGACGCGCCACTCTCTGATGAAGAATTCGAGCGGGGCCGCGCGGCGGTATTGGCCCG
CAAGGCGCGCTCGGCGACGGGGCTGAGCCAGCCTGCATTTGCCGCGCGCTATGGCGTACCGGTGGCGAGCCTTCGCGACT
GGGAGCAGGGCAGGCGCAAGCCGGATGCCGCCACGCGCAACTATCTGCGCGTGATCGCATCCATGCCGGACGCGGTGGCG
CGCGCGCTTGACGGCGCAGCCTGA