Detailed information of TA system TA070804

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 1193505..1194039
• Replicon: chromosome
• Accession: NZ_CP018911
• Organism: Glycocaulis alkaliphilus strain 6B-8

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: X907_RS05695
• Protein ID: WP_170175475.1
• Coordinates: 1193505..1193795 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: X907_RS05700
• Protein ID: WP_127566101.1
• Coordinates: 1193785..1194039 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
X907_RS05665	1188642..1189211	+	570	WP_127566087.1	Fic family protein	-
X907_RS05670	1189433..1189912	+	480	WP_127566089.1	hypothetical protein	-
X907_RS05675	1190009..1192243	-	2235	WP_127566091.1	phosphoribosylformylglycinamidine synthase subunit PurL	-
X907_RS05680	1192240..1192548	-	309	WP_127566093.1	type II toxin-antitoxin system HicB family antitoxin	-
X907_RS05685	1192554..1192751	-	198	WP_127566095.1	type II toxin-antitoxin system HicA family toxin	-
X907_RS05690	1192751..1193413	-	663	WP_127566097.1	phosphoribosylformylglycinamidine synthase subunit PurQ	-
X907_RS05695	1193505..1193795	-	291	WP_170175475.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
X907_RS05700	1193785..1194039	-	255	WP_127566101.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
X907_RS05705	1194200..1194553	+	354	WP_127566103.1	VOC family protein	-
X907_RS05710	1194719..1194961	-	243	WP_127566105.1	phosphoribosylformylglycinamidine synthase subunit PurS	-
X907_RS05715	1194975..1195757	-	783	WP_127566107.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
X907_RS05720	1196020..1196340	+	321	WP_127566109.1	DUF1476 domain-containing protein	-
X907_RS05725	1196343..1197641	-	1299	WP_127566111.1	adenylosuccinate lyase	-
X907_RS05730	1197704..1198165	-	462	WP_127566113.1	ribonuclease HI	-
X907_RS05735	1198162..1198590	-	429	WP_127566115.1	DUF1801 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10739.30 Da
• Isoelectric Point: 7.1998

>T70804 WP_170175475.1 NZ_CP018911:c1193795-1193505 [Glycocaulis alkaliphilus]
MRIELSTRAAADLRNLYLQGAEDFGILQAENYLATLEDSLRLIGEFPYAGTAGNSTDPTLRAYSVKSHRILYRIRDGSVP
LIIRILHARQLPPELA

Nucleotide

• Length: 291 bp

>T70804 NZ_CP018911:c1193795-1193505 [Glycocaulis alkaliphilus]
ATGCGGATTGAACTCAGCACGAGAGCTGCCGCCGATCTGCGCAATCTATACCTGCAAGGCGCAGAAGATTTCGGCATCCT
CCAAGCGGAAAACTATCTGGCAACGCTGGAAGATTCACTTAGGCTGATCGGAGAGTTTCCCTATGCTGGAACCGCAGGCA
ATTCCACTGATCCAACTCTTCGGGCTTACAGCGTGAAATCACACCGCATCCTATACCGGATCCGCGACGGCAGTGTGCCG
CTCATAATCCGCATCCTCCACGCCCGCCAGCTTCCGCCCGAGCTGGCGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9429.41 Da
• Isoelectric Point: 4.6838

>AT70804 WP_127566101.1 NZ_CP018911:c1194039-1193785 [Glycocaulis alkaliphilus]
MATMNISLPDALKSVVDSQVGSGQYASASDYVRDLIRRDEENRRKRAEFERLIQEGIDSGVSEKSFDEVMADARAEAKRR
GYAD

Nucleotide

• Length: 255 bp

>AT70804 NZ_CP018911:c1194039-1193785 [Glycocaulis alkaliphilus]
ATGGCCACGATGAATATCTCCCTGCCCGACGCCCTGAAATCGGTGGTCGATTCTCAGGTAGGGTCCGGCCAGTACGCCAG
CGCCAGCGACTATGTACGCGACCTGATCCGGCGTGATGAAGAGAACCGCCGCAAGCGCGCCGAGTTCGAGCGGCTCATCC
AGGAAGGCATCGATAGCGGCGTCAGCGAAAAATCATTCGACGAGGTGATGGCGGATGCCCGCGCCGAAGCCAAACGGCGC
GGCTATGCGGATTGA