Detailed information of TA system TA070802

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 35066..35628
• Replicon: chromosome
• Accession: NZ_CP018911
• Organism: Glycocaulis alkaliphilus strain 6B-8

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: X907_RS00195
• Protein ID: WP_127565060.1
• Coordinates: 35066..35434 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: X907_RS00200
• Protein ID: WP_127565061.1
• Coordinates: 35431..35628 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
X907_RS00180	31940..33631	-	1692	WP_127565058.1	amidohydrolase	-
X907_RS00185	33745..34038	-	294	WP_127565059.1	50S ribosomal protein L28	-
X907_RS00190	34290..35069	+	780	WP_127569201.1	DUF3108 domain-containing protein	-
X907_RS00195	35066..35434	-	369	WP_127565060.1	type II toxin-antitoxin system VapC family toxin	Toxin
X907_RS00200	35431..35628	-	198	WP_127565061.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
X907_RS00205	35751..38357	+	2607	WP_127565062.1	ATP-dependent DNA helicase	-
X907_RS00210	38354..38665	+	312	WP_127565063.1	RNA-binding S4 domain-containing protein	-
X907_RS00215	38745..39086	+	342	WP_127565064.1	ferredoxin family protein	-
X907_RS00220	39327..39844	+	518	Protein_43	CarD family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-111)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-46)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13007.94 Da
• Isoelectric Point: 5.4916

>T70802 WP_127565060.1 NZ_CP018911:c35434-35066 [Glycocaulis alkaliphilus]
MILVDTSVWVDHLRSGEPHLAGLLMNGQAVCHPFIIGELALGNLSDRADILADLENLPAAPVAADEEVRRLIDQHGLAGS
GIGYVDAHLAASAKLGALQGLWTRDRRLARVLDRLGLAVNFA

Nucleotide

• Length: 369 bp

>T70802 NZ_CP018911:c35434-35066 [Glycocaulis alkaliphilus]
TTGATCCTCGTCGACACATCGGTGTGGGTAGATCATCTGCGTTCCGGCGAGCCGCATCTGGCGGGTCTGCTGATGAATGG
TCAGGCCGTGTGCCATCCCTTCATCATTGGTGAGCTGGCACTTGGAAACCTGTCAGACCGGGCGGATATTCTGGCTGATC
TGGAAAACCTGCCCGCCGCGCCCGTGGCCGCTGATGAGGAGGTGCGCCGCCTTATCGATCAGCACGGTCTTGCGGGCAGC
GGTATCGGTTATGTTGACGCACATCTTGCCGCATCGGCAAAGCTGGGTGCGCTGCAAGGCTTATGGACCCGCGACAGGCG
TCTGGCGCGGGTCCTTGACCGGCTCGGCCTGGCTGTGAATTTCGCCTAG

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7307.47 Da
• Isoelectric Point: 10.4418

>AT70802 WP_127565061.1 NZ_CP018911:c35628-35431 [Glycocaulis alkaliphilus]
MRTTLNLDDALLEKAVKLTGIEERAALVREAMKALIERESARRLARLGGTQPDLRPVPRRQDEPA

Nucleotide

• Length: 198 bp

>AT70802 NZ_CP018911:c35628-35431 [Glycocaulis alkaliphilus]
ATGCGTACGACCTTGAACCTTGATGACGCGCTGCTCGAAAAGGCCGTAAAGCTTACAGGTATTGAAGAGCGCGCTGCCCT
GGTGCGCGAAGCCATGAAGGCCCTGATCGAGCGCGAGAGCGCGCGCCGCCTTGCCCGGCTGGGGGGCACTCAGCCAGATC
TGCGGCCCGTTCCCCGGCGGCAGGACGAACCGGCTTGA