Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 2932795..2933381 Replicon chromosome
Accession NZ_CP018889
Organism Beggiatoa leptomitoformis strain D-401

Toxin (Protein)


Gene name mazF Uniprot ID A0A2N9YFS5
Locus tag BLE401_RS12335 Protein ID WP_062153245.1
Coordinates 2932795..2933058 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2N9YG31
Locus tag BLE401_RS12340 Protein ID WP_062153247.1
Coordinates 2933046..2933381 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLE401_RS12305 2930137..2930877 - 741 WP_062153239.1 hypothetical protein -
BLE401_RS12310 2931058..2931384 - 327 WP_101539184.1 hypothetical protein -
BLE401_RS12315 2931381..2931758 - 378 WP_062153243.1 helix-turn-helix domain-containing protein -
BLE401_RS12320 2931866..2932009 + 144 WP_161575464.1 hypothetical protein -
BLE401_RS12325 2932006..2932170 + 165 WP_161575465.1 hypothetical protein -
BLE401_RS12330 2932258..2932539 + 282 WP_083991516.1 site-specific integrase -
BLE401_RS12335 2932795..2933058 + 264 WP_062153245.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
BLE401_RS12340 2933046..2933381 + 336 WP_062153247.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
BLE401_RS12350 2933787..2934131 - 345 WP_062153248.1 hypothetical protein -
BLE401_RS12355 2934160..2934786 - 627 WP_062155510.1 hypothetical protein -
BLE401_RS12360 2935318..2936568 - 1251 WP_062153250.1 SpoIIE family protein phosphatase -
BLE401_RS12365 2936850..2937059 + 210 WP_062153252.1 DUF2788 domain-containing protein -
BLE401_RS12370 2937121..2938065 + 945 WP_062153254.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

mRNA interferase PemK-like

(7-108)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9900.23 Da        Isoelectric Point: 4.3719

>T70779 WP_062153245.1 NZ_CP018889:2932795-2933058 [Beggiatoa leptomitoformis]
MATILQTSLVKIGNSRGVRIPKSSLQQLGIIDGKIEMELTDNELIIRPLRVARQGWDVQFQKMANNGDDTLLDESGLTTE
WDSEWQW

Download         Length: 264 bp

>T70779 NZ_CP018889:2932795-2933058 [Beggiatoa leptomitoformis]
ATGGCAACTATTTTACAAACTAGCTTGGTTAAAATAGGTAATTCCCGTGGGGTGCGCATTCCTAAGTCCTCATTGCAACA
ATTGGGAATTATTGATGGTAAAATTGAAATGGAACTCACTGATAATGAATTGATTATCCGTCCATTACGTGTAGCACGGC
AAGGTTGGGATGTGCAGTTTCAAAAGATGGCAAACAATGGCGATGATACATTATTAGATGAATCAGGATTAACAACTGAA
TGGGATAGCGAATGGCAGTGGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12317.52 Da        Isoelectric Point: 8.7642

>AT70779 WP_062153247.1 NZ_CP018889:2933046-2933381 [Beggiatoa leptomitoformis]
MAVVNVKRFDIFLVNLDPTVGAEIQKTRPCLIISPDEMNQSISTVIIAPMTTVTRVGYPTRVDCSFNGKSGQIVLDQIRT
VDKKRLVKQLGCIQKAEQQVVIDVLQSLFAL

Download         Length: 336 bp

>AT70779 NZ_CP018889:2933046-2933381 [Beggiatoa leptomitoformis]
ATGGCAGTGGTAAATGTTAAGCGGTTTGATATTTTTTTAGTGAATCTTGATCCAACTGTGGGGGCAGAAATTCAAAAAAC
GCGTCCTTGTTTGATTATTTCTCCTGATGAGATGAATCAATCTATTTCAACTGTTATTATCGCTCCCATGACTACAGTTA
CTCGAGTTGGTTATCCTACCCGTGTTGATTGTTCTTTTAATGGAAAAAGTGGGCAGATAGTGTTGGACCAAATACGCACA
GTCGATAAAAAACGGTTGGTTAAACAGTTGGGATGTATTCAAAAAGCAGAACAGCAAGTAGTCATTGATGTTTTGCAATC
GCTTTTTGCGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N9YFS5

Antitoxin

Source ID Structure
AlphaFold DB A0A2N9YG31

References